Sex differences in nicotine-induced impulsivity and its reversal with bupropion in rats
| Autor: | Arbi Nazarian, Javier Íbias |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Nicotine Nicotinic Antagonists Impulsivity Article Rats Sprague-Dawley 03 medical and health sciences Sex Factors 0302 clinical medicine medicine Animals Pharmacology (medical) Nicotinic Agonists Bupropion 030304 developmental biology Pharmacology Sex Characteristics 0303 health sciences Behavior Animal Delay discounting business.industry Cognition Rats Psychiatry and Mental health Delay Discounting Impulsive Behavior Female medicine.symptom business 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | J Psychopharmacol |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | Background: Enhancement in cognitive impulsivity and the resulting alterations in decision making serve as a contributing factor for the development and maintenance of substance-use disorders. Nicotine-induced increases in impulsivity has been previously reported in male humans and rodents. Although the potential for sex differences in nicotine-induced impulsivity has not been examined. Aims and methods: In the present study, male and female Sprague Dawley rats were submitted to a delay discounting task, in which several consecutive measures of self-control were taken. Firstly, rats were tested with vehicle, and next with nicotine doses of 0.4 and 0.8 mg/kg. Thereafter, chronic treatment with bupropion started, and the animals were tested again. Half the animals continued to receive 0.8 mg/kg of nicotine, while the rest received nicotine and also a daily dose of 30 mg/kg of bupropion. Results: When the animals were first tested with nicotine, female rats showed a significant nicotine dose dependent increase of impulsive behaviour, whereas male rats only showed a decrease on their elections of the larger but delayed reward under the highest dose of 0.8 mg/kg of nicotine. Treatment with bupropion blocked the effect of nicotine on decision making in female rats, as they showed results close to their baseline levels. On the other hand, bupropion did not affect the nicotine-induced delay discounting in male rats. Conclusion: These findings demonstrate sexually dimorphic effects of nicotine on cognitive impulsivity which may help to shed light on nicotine use vulnerabilities observed in women. |
| Databáze: | OpenAIRE |
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