Epigenetic Alterations in a Gastric Leiomyoma
Autor: | A. Correa, M. Palma, Emanuel M. Campoy, Maria Teresita Branham, M. Pellicer, María Roqué |
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Rok vydání: | 2014 |
Předmět: |
History
Pathology medicine.medical_specialty Polymers and Plastics DNA repair GASTRIC LEIOMYOMA Case Report Biology MLH1 Industrial and Manufacturing Engineering Ciencias Biológicas purl.org/becyt/ford/1 [https] medicine Epigenetics lcsh:RC799-869 Business and International Management purl.org/becyt/ford/1.6 [https] DNA METHYLATION neoplasms EPIGENETIC Microsatellite instability Methylation Bioquímica y Biología Molecular medicine.disease digestive system diseases MSH6 MSH3 Gastric Leiomyoma lcsh:Diseases of the digestive system. Gastroenterology CIENCIAS NATURALES Y EXACTAS |
Zdroj: | Case Reports in Gastrointestinal Medicine, Vol 2014 (2014) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Case Reports in Gastrointestinal Medicine |
ISSN: | 2090-6536 2090-6528 |
DOI: | 10.1155/2014/371638 |
Popis: | Leiomyomas constitute 2.5% of all resected neoplasms of the stomach. They are usually asymptomatic, but may present mucosal ulceration. Aberrant DNA methylation is a well-defined epigenetic change in human neoplasms; however, gene-acquired methylation may not necessarily be related with a malignant phenotype. In this report we analyzed in a gastric leiomyoma, the methylation status of 84 CpGI in tumor suppressor and DNA repair genes. We analyzed the tumor center (TC) and tumor periphery (TP) separately. We found aberrant methylation in 2/84 CpGI in the TC portion, that is, MLH1 and MSH3, and 5/84 CpGI in the TP, that is, MLH1, MSH3, APC, MSH6, and MGMT.The gene with the highest methylation percentage in the TC and TP was MLH1. Given that MLH1methylation has been associated withmicrosatellite instability, we analyzed the status of themicrosatellite Bat-26. We found that neither the TC nor the TP presented instability.The methylation of MLH1, MGMT, and APC has been described in GISTs, but to the best of our knowledge this is the first time that the methylation of these genes has been associated with gastric leiomyoma. Further research should be conducted to identify reliable molecular markers that could differentiate between GISTs and gastric leiomyomas. Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Pellicer, Monica. Laboratorio de Patología; Argentina Fil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Palma, Marcelo. Provincia de Entre Rios. Hospital San Martin; Argentina Fil: Correa, Agustín. Hospital Español; Argentina Fil: Roqué, Monica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina |
Databáze: | OpenAIRE |
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