Gut Microbiota and Breast Cancer: The Dual Role of Microbes

Autor: Ana Isabel Álvarez-Mercado, Ana del Valle Cano, Mariana F. Fernández, Luis Fontana
Rok vydání: 2023
Předmět:
Zdroj: Cancers. 15:443
ISSN: 2072-6694
0538-2017
DOI: 10.3390/cancers15020443
Popis: Breast cancer is the most frequently diagnosed cancer and also one of the leading causes of mortality among women. The genetic and environmental factors known to date do not fully explain the risk of developing this disease. In recent years, numerous studies have highlighted the dual role of the gut microbiota in the preservation of host health and in the development of different pathologies, cancer among them. Our gut microbiota is capable of producing metabolites that protect host homeostasis but can also produce molecules with deleterious effects, which, in turn, may trigger inflammation and carcinogenesis, and even affect immunotherapy. The purpose of this review is to describe the mechanisms by which the gut microbiota may cause cancer in general, and breast cancer in particular, and to compile clinical trials that address alterations or changes in the microbiota of women with breast cancer.
Junta de Andalucia PI-0538-2017 B-CTS-254-UGR18 B-CTS-254-UGR18 RPS 24665
Programa Operativo FEDER Andalucia 2014-2020, Junta de Andalucia, Spain RPS 24665
Databáze: OpenAIRE
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