The Nasopharyngeal and Gut Microbiota in Children in a Pediatric Otolaryngology Practice
| Autor: | Carter M Denne, Santosh Thapa, Ruth Ann Luna, Jack B. Anon, Alamelu Venkatachalam, Jessica K. Runge |
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| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty medicine.drug_class Antibiotics Gut flora 03 medical and health sciences Otolaryngology 0302 clinical medicine Antibiotic resistance 030225 pediatrics Internal medicine Nasopharynx RNA Ribosomal 16S Medicine Humans 030212 general & internal medicine Microbiome Child Qualitative Research biology Bacteria business.industry Microbiota Human microbiome Infant biology.organism_classification Delivery mode Gastrointestinal Microbiome Infectious Diseases Child Preschool Pediatrics Perinatology and Child Health Female Sample collection Bacteroides business Family Practice |
| Zdroj: | The Pediatric infectious disease journal. 39(9) |
| ISSN: | 1532-0987 |
| Popis: | BACKGROUND The human microbiome evolves rapidly in early life with contributions from various factors such as diet, delivery mode, medical history, antibiotics exposure, genetics, immunomodulators and the environment. A high use of antibiotics in pediatric outpatient settings has been well documented, and improvement in antibiotic selection is required to reduce the risks of antibiotic resistance and disruption of the microbiome. METHODS We performed an exploratory study using 16S rRNA gene-based sequencing to characterize the gut and nasopharyngeal microbiome of children (n = 50) age 1-6 years of age in a pediatric otolaryngology practice. RESULTS Relative abundance of Haemophilus and Moraxella were higher in nasopharyngeal swabs, while Prevotella, Bacteroides, Porphyromonas and Faecalibacterium were highly abundant in rectal swabs. The gut microbiome composition in children |
| Databáze: | OpenAIRE |
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