Circulating miRNAs are associated with sleep duration in children/adolescents: results of the I.Family Study
| Autor: | Barbara F. Thumann, Idefics, Luis A. Moreno, Pasquale Marena, Ronja Foraita, Yiannis Kourides, Antonella Venezia, Toomas Veidebaum, Regina Heidinger-Felső, Monica Hunsberger, Fabio Lauria, Nunzia Iannaccone, Paola Russo, Stefaan De Henauw, Giuseppe Iacomino, Alfonso Siani |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Circulating mirnas
Male medicine.medical_specialty Adolescent Physiology 030204 cardiovascular system & hematology Health outcomes Cohort Studies 03 medical and health sciences Screen time 0302 clinical medicine Physiology (medical) Internal medicine Medicine Humans Circadian rhythm Registries Child PUBMED Nutrition and Dietetics business.industry General Medicine Sleep in non-human animals Circadian Rhythm Circulating MicroRNA MicroRNAs Early adolescents Female Self Report business Sleep 030217 neurology & neurosurgery Biomarkers Sleep duration |
| Zdroj: | Experimental physiology (2020). doi:10.1113/EP088015 info:cnr-pdr/source/autori:Giuseppe Iacomino1, Fabio Lauria1, Paola Russo1, Pasquale Marena1, Antonella Venezia1, Nunzia Iannaccone1, Stefaan De Henauw2, Ronja Foraita3, Regina Heidinger-Fels?4, Monica Hunsberger5, Yiannis Kourides6, Luis A Moreno7, Barbara Thumann3, Toomas Veidebaum8, Alfonso Siani1/titolo:Circulating miRNAs are associated with sleep duration in children%2Fadolescents: results of the I.Family Study/doi:10.1113%2FEP088015/rivista:Experimental physiology (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume |
| DOI: | 10.1113/EP088015 |
| Popis: | What is the central question of this study? Are differential patterns of circulating miRNAs associated with sleep duration in normal-weight European children and adolescents? What is the main finding and its importance? Differences in the expression level of circulating miR-26b-3p and miR-485-5p are positively associated with total sleep duration in healthy normal-weight children and adolescents.It is commonly recognized that sleep is essential for children's health, and that insufficient sleep duration is associated with negative health outcomes. In humans, sleep duration and quality are influenced by genetic, environmental and social factors. Epigenetic mechanisms, likewise, regulate circadian rhythms and sleep patterns. In the present study, we aimed to identify circulating microRNAs associated with sleep duration in a subsample of normal-weight European children/adolescents (n = 111) participating in the I.Family Study. Subjects were divided into two groups based upon self-reported sleep duration, according to the recommended amount of sleep for paediatric populations. Sleep needs for children 13 years were at least 9 h per day, and for children 13 were at least 8 h per day. There were group differences (short sleepers versus normal sleepers) in circulating levels of miR-26b-3p (mean (95% CI) = 2.0 (1.3-2.7) versus 2.3 (1.9-2.7), P = 0.05) and miR-485-5p (mean (95% CI) = 0.6 (0.3-0.9) versus 0.9 (0.7 - 1.0), P 0.001), adjusting for country of origin, age, sex, pubertal status, screen time and highest educational level of parents. Our findings show for the first time that sleep duration reflects the profile of specific circulating microRNAs in school-aged children and adolescents. It is conceivable that epigenetic modifications, mainly related to circadian rhythm control, may be modulated or interfere with sleep duration. |
| Databáze: | OpenAIRE |
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