Trends in Resistance to Extended-Spectrum Cephalosporins and Carbapenems among Escherichia coli and Klebsiella spp. Isolates in a District in Western India during 2004–2014
| Autor: | Sandeep S. Nerkar, Frida Lind, Uday Khedkar, Cecilia Stålsby Lundborg, Ingvild Odsbu, Nicola Orsini, Smita U. Khedkar, Ashok J. Tamhankar |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Veterinary medicine Carbapenem Klebsiella antibiotic resistance medicine.drug_class Health Toxicology and Mutagenesis 030106 microbiology Cephalosporin Antibiotics India lcsh:Medicine Microbial Sensitivity Tests medicine.disease_cause Escherichia coli ESBL cephalosporins carbapenems non-susceptible antimicrobial susceptibility testing Klebsiella spp beta-Lactamases Article 03 medical and health sciences 0302 clinical medicine Antibiotic resistance medicine Humans 030212 general & internal medicine Escherichia coli Infections biology lcsh:R Public Health Environmental and Occupational Health Drug Resistance Microbial biology.organism_classification Anti-Bacterial Agents Klebsiella Infections Female Bacteria medicine.drug |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 15, Iss 1, p 155 (2018) International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 15; Issue 1; Pages: 155 |
| ISSN: | 1660-4601 |
| Popis: | Surveillance data on the level of resistant bacteria is needed to inform strategies to reduce the development and spread of antibiotic resistance. The aim of this study was to determine the non-susceptibility trends to extended-spectrum cephalosporins and carbapenems among Escherichia coli and Klebsiella spp. isolates from the district of Nashik in Western India during the period 2004–2014. Antibacterial susceptibility testing of clinical isolates was performed using Kirby-Bauer disc diffusion method to determine inhibitory zone diameters. The change in proportions of non-susceptible bacteria over calendar time was investigated with spline transformations in a logistic regression model. For the extended-spectrum cephalosporins, the proportions of non-susceptible E. coli and Klebsiella spp. isolates were above 78.4% and 84.9% throughout the study period, respectively. E. coli and Klebsiella spp. isolates exhibited carbapenem non-susceptibility levels as high as 76.9% and 84.1% respectively. The proportions of extended-spectrum betalactamase (ESBL)-producing isolates ranged from 38.3–85.9% in E. coli and from 45.1–93.1% in Klebsiella spp. Significantly higher proportions of non-susceptible and ESBL-producing isolates were found among isolates from inpatients compared to isolates from outpatients for both E. coli and Klebsiella spp. (p < 0.050). The high proportions of non-susceptible isolates observed show that there is great need to focus on optimal use of antibiotics to reduce the development of antibiotic resistance. |
| Databáze: | OpenAIRE |
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