ANTAGONISM OF VASODEPRESSOR AND GASTRIC SECRETORY RESPONSES TO HISTAMINE BY THE H2-RECEPTOR ANTAGONISTS, RANITIDINE AND CIMETIDINE, IN THE ANAESTHETIZED DOG
| Autor: | J. M. Humphray, R. Stables, M.J. Daly |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
medicine.medical_specialty Mepyramine Blood Pressure Pharmacology Ranitidine Guanidines Gastric Acid chemistry.chemical_compound Dogs Histamine H2 receptor Internal medicine medicine Animals Anesthesia Cimetidine Furans Pyrilamine Dose-Response Relationship Drug Chemistry Antagonist Effective dose (pharmacology) Endocrinology Histamine H2 Antagonists Gastric acid Female Histamine Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 72:55-60 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1981.tb09104.x |
| Popis: | 1 The new H2-receptor antagonist, ranitidine, has been compared with cimetidine as an inhibitor of gastric acid secretion in the anaesthetized dog. 2 Both ranitidine and cimetidine given intravenously inhibited histamine-induced gastric secretion in a dose-related manner. Ranitidine was 4.2 times more potent than cimetidine when given as an intravenous infusion and 9.6 times more potent as an intravenous bolus dose. 3 In a separate series of experiments, ranitidine was compared with cimetidine as an antagonist of vasodepressor responses to histamine. Mepyramine alone displaced the histamine dose-response curve to the right. After a maximally effective dose of mepyramine, further displacement could be achieved with ranitidine and cimetidine, ranitidine being 19.2 times more potent than cimetidine. 4 Ranitidine alone has no effect on vasodepressor response curves to histamine, acetylcholine or (-)-isoprenaline or on vasopressor response curves to phenylephrine. 5 These results indicate that displacement of the histamine dose-response curve after mepyramine blockade by ranitidine and cimetidine is due to selective H2-receptor antagonism. |
| Databáze: | OpenAIRE |
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