Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type
| Autor: | Mark Gruppetta, Annalisa Montebello |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
musculoskeletal diseases
Adult medicine.medical_specialty Hypercalcaemia endocrine system diseases medicine.medical_treatment 030209 endocrinology & metabolism Carcinoma Ovarian Epithelial Small-cell carcinoma 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases medicine Endocrine system Humans Carcinoma Small Cell Etoposide Ovarian Neoplasms Chemotherapy Diphosphonates business.industry nutritional and metabolic diseases General Medicine medicine.disease Ovarian Small Cell Carcinoma Pathophysiology 030220 oncology & carcinogenesis Hypercalcemia Female Radiology Differential diagnosis business medicine.drug |
| Zdroj: | BMJ case reports. 14(7) |
| ISSN: | 1757-790X |
| Popis: | A 37-year-old woman presented with a few days’ history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour—ovarian small cell carcinoma of the hypercalcaemic type. Acute treatment of hypercalcaemia consisted of aggressive intravenous fluids and bisphosphonates. She underwent surgery to remove the tumour and is currently receiving systemic platinum/etoposide chemotherapy combination to be followed by pelvic radiotherapy. This case highlights the wide range of differential diagnosis for hypercalcaemia and the importance of a stepwise and thorough approach during investigations. We discuss the pathophysiology of malignancy-related hypercalcaemia, focusing especially on parathyroid hormone-related peptide-associated hypercalcaemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|