Organic nanoparticle tracking during pharmacokinetic studies
| Autor: | Samuel Bonnet, Rana Elfatairi, Samuel Legeay, Florence Franconi, Emilie Roger |
|---|---|
| Přispěvatelé: | Plate-forme de Recherche en Imagerie et Spectroscopie Multi-modales (PRISM [SFR ICAT - UA]), SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques (ICAT), Université d'Angers (UA)-Université d'Angers (UA), Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Legeay, Samuel, Plate-forme de Recherche en Imagerie et Spectroscopie Multi-modales [SFR ICAT - UA] (PRISM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Biodistribution [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication education Biomedical Engineering Medicine (miscellaneous) Nanoparticle Bioengineering Nanotechnology 02 engineering and technology Development 010402 general chemistry Tracking (particle physics) 01 natural sciences Pharmacokinetics [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication In vivo Fluorescence Resonance Energy Transfer General Materials Science health care economics and organizations Chemistry technology industry and agriculture Structural integrity 021001 nanoscience & nanotechnology 0104 chemical sciences Förster resonance energy transfer Nanoparticles Nanomedicine 0210 nano-technology |
| Zdroj: | Nanomedicine Nanomedicine, Future Medicine, 2021, ⟨10.2217/nnm-2021-0155⟩ Nanomedicine, 2021, ⟨10.2217/nnm-2021-0155⟩ |
| ISSN: | 1743-5889 1748-6963 |
| DOI: | 10.2217/nnm-2021-0155⟩ |
| Popis: | International audience; To understand how nanoparticles (NPs) interact with biological barriers and to ensure they maintain their integrity over time, it is crucial to study their in vivo pharmacokinetic (PK) profiles. Many methods of tracking have been used to describe the in vivo fate of NPs and to evaluate their PKs and structural integrity. However, they do not deliver the same level of information and this may cause misinterpretations. Here, the authors review and discuss the different methods for in vivo tracking of organic NPs. Among them, Förster resonance energy transfer (FRET) presents great potential to track NPs' integrity. However, FRET still requires validated methods to extract and quantify NPs in biological fluids and tissues. |
| Databáze: | OpenAIRE |
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