Higher Incidence of Hemorrhagic Cystitis Following Haploidentical Related Donor Transplantation Compared with Matched Related Donor Transplantation
| Autor: | Ryan Jacobs, Jing Ai, Olivia Copelan, Brittany K. Ragon, Zainab Shahid, James T. Symanowski, Jiaxian He, Saad Z. Usmani, Michael R. Grunwald, Nilanjan Ghosh, Thomas G. Knight, Jigar Trivedi, Srinivasa R. Sanikommu, Peter E. Clark, Candace Butler |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning Adolescent Cyclophosphamide medicine.medical_treatment Population Hemorrhage medicine.disease_cause Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Cystitis medicine Humans education Aged Transplantation education.field_of_study business.industry Incidence Hematopoietic Stem Cell Transplantation Immunosuppression Hematology Middle Aged medicine.disease BK virus Regimen surgical procedures operative 030220 oncology & carcinogenesis Transplantation Haploidentical Female business Complication 030215 immunology Hemorrhagic cystitis medicine.drug |
| Zdroj: | Biology of Blood and Marrow Transplantation. 25:785-790 |
| ISSN: | 1083-8791 |
| DOI: | 10.1016/j.bbmt.2018.12.142 |
| Popis: | Hemorrhagic cystitis (HC) is a common and important complication of allogeneic hematopoietic cell transplantation (HCT). Reactivation of BK virus is its most common cause. The more intense immunosuppressive regimens administered to recipients of grafts from alternative donors have been reported to account for the increased susceptibility to HC in this population. This study compares patients undergoing HCT with either a haploidentical donor or a matched related donor, all of whom received identical immunosuppression with a post-transplantation cyclophosphamide-based regimen. The incidence of HC was significantly higher in the patients receiving a haploidentical graft (P = .01). The higher incidence of HC in haploidentical graft recipients is therefore directly related to the inherent immune deficiency that follows HLA-mismatched transplantation, independent of the intensity of pharmacologic immunosuppression. This finding carries significant clinical impact for the prevention and treatment of HC in haploidentical graft recipients. |
| Databáze: | OpenAIRE |
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