Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937

Autor: Michael Goodfellow, James E. M. Stach, Claudia Hohmann, Graeme J. Nicholson, Johannes F. Imhoff, Marco Krämer, Roselyn Brown, Alan T. Bull, Roderich D. Süssmuth, Hans-Peter Fiedler, Amanda Jones, Winfried Beil, Christina Bruntner, Kathrin Schneider, Elisabeth Irran
Rok vydání: 2009
Předmět:
Models
Molecular
Spectrometry
Mass
Electrospray Ionization
Magnetic Resonance Spectroscopy
Spectrophotometry
Infrared
Cell Survival
Electrospray ionization
Drug Evaluation
Preclinical
Molecular Conformation
Microbial Sensitivity Tests
Gram-Positive Bacteria
01 natural sciences
Streptomyces
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Cell Line
Tumor
Drug Discovery
Humans
Seawater
030304 developmental biology
Pharmacology
chemistry.chemical_classification
Benzoxazoles
0303 health sciences
Antibiotics
Antineoplastic
biology
Strain (chemistry)
010405 organic chemistry
Phosphodiesterase
Benzoxazole
biology.organism_classification
Anti-Bacterial Agents
0104 chemical sciences
Enzyme
chemistry
Biochemistry
Fermentation
Spectrophotometry
Ultraviolet
Drug Screening Assays
Antitumor
Water Microbiology
Bacteria
Zdroj: Journal of Antibiotics, 62 . pp. 99-104.
ISSN: 1881-1469
0021-8820
DOI: 10.1038/ja.2008.24
Popis: Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
Databáze: OpenAIRE
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