FDG-PET for Prediction of AD Dementia in Mild Cognitive Impairment. A Review of the State of the Art with Particular Emphasis on the Comparison with Other Neuroimaging Modalities (MRI and Perfusion SPECT)

Autor: Peter Paul De Deyn, Mario Alvarez Sanchez, Rudi Dierckx, Peter Jan van Laar, Gilles N. Stormezand, Carlos A. Sánchez-Catasús
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
NATIONAL INSTITUTE
Perfusion scanning
Single-photon emission computed tomography
0302 clinical medicine
perfusion SPECT
F-18-FDG PET
FDG-PET
education.field_of_study
medicine.diagnostic_test
GLUCOSE-METABOLISM
Alzheimer's disease
ALZHEIMERS ASSOCIATION WORKGROUPS
Magnetic Resonance Imaging
Neurology
Positron emission tomography
Disease Progression
Psychology
BRAIN PERFUSION
medicine.drug
MRI
Population
POSTERIOR CINGULATE CORTEX
Neuroimaging
03 medical and health sciences
mild cognitive impairment
POSITRON-EMISSION-TOMOGRAPHY
CEREBROSPINAL-FLUID
Alzheimer Disease
Fluorodeoxyglucose F18
medicine
Humans
Dementia
Cognitive Dysfunction
education
Tomography
Emission-Computed
Single-Photon
Fluorodeoxyglucose
business.industry
BLOOD-FLOW SPECT
Magnetic resonance imaging
medicine.disease
carbohydrates (lipids)
030104 developmental biology
Positron-Emission Tomography
DIAGNOSTIC GUIDELINES
Human medicine
Neurology (clinical)
Radiopharmaceuticals
Nuclear medicine
business
030217 neurology & neurosurgery
dementia
Zdroj: Current Alzheimer research
ISSN: 1567-2050
DOI: 10.2174/1567205013666160629081956
Popis: This review article aims at providing a state-of-the-art review of the role of fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging (FDG-PET) in the prediction of Alzheimer's dementia in subjects suffering mild cognitive impairment (MCI), with a particular focus on the predictive power of FDG-PET compared to structural magnetic resonance imaging (sMRI). We also address perfusion single photon emission computed tomography (SPECT) as a less costly and more accessible alternative to FDG-PET. A search in PubMed was performed, taking into consideration relevant scientific articles published in English within the last five years and limited to human studies. This recent literature confirms the effectiveness of FDG-PET and sMRI for prediction of AD dementia in MCI. However, there are discordant results regarding which image modality is superior. This could be explained by the high variability of metrics used to evaluate both imaging modalities and/or by sampling/population issues such as age, disease severity and conversion time. FDG-PET seems to outperform sMRI in rapidly converting early-onset MCI individuals, whereas sMRI may outperform FDG-PET in late-onset MCI subjects, in which case FDG PET might only provide a complementary role. Although FDG-PET performs better than perfusion SPECT, current evidence confirms perfusion SPECT as a valid alternative when FDG- PET is not available. Finally, possible future directions in the field are discussed.
Databáze: OpenAIRE
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