Genomic and phenotypic characterisation of antimicrobial resistance in carbapenem-resistant Acinetobacter baumannii hyperendemic clones CC1, CC15, CC79 and CC25
| Autor: | Elizabeth Harummyy Takagi, Marcos Paulo Vieira Cunha, Mariana Bueno, Enéas de Carvalho, Amanda Maria de Jesus Bertani, Carla Adriana Dos Santos, Erica Chimara, Monique Ribeiro Tiba-Casas, Carlos Henrique Camargo, Filipe Onishi Nagamori, Thays Almeida Franco de Barcellos |
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| Rok vydání: | 2020 |
| Předmět: |
Acinetobacter baumannii
0301 basic medicine Microbiology (medical) 030106 microbiology Single-nucleotide polymorphism Microbial Sensitivity Tests Biology Polymorphism Single Nucleotide beta-Lactamases Microbiology 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Bacterial Proteins Phylogenetics Drug Resistance Multiple Bacterial Humans Pharmacology (medical) Polymyxins 030212 general & internal medicine Phylogeny Molecular Epidemiology Whole Genome Sequencing Molecular epidemiology General Medicine biology.organism_classification Phenotype Hospitals Anti-Bacterial Agents Infectious Diseases Carbapenems Multilocus sequence typing Carbapenem resistant Acinetobacter baumannii Brazil Genome Bacterial Multilocus Sequence Typing |
| Zdroj: | International Journal of Antimicrobial Agents. 56:106195 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2020.106195 |
| Popis: | Dissemination of carbapenem-resistant Acinetobacter baumannii (CRAB) is mainly driven by the spread of clonal lineages. High frequencies of CRAB are reported in South America, and clonal complexes CC1, CC15, CC79 and CC25 are predominant. A total of 79 non-redundant CRAB recovered from 26 Brazilian hospitals were selected for antimicrobial susceptibility testing by microdilution and whole-genome sequencing (WGS). Multilocus sequence typing (MLST), acquired antimicrobial resistance genes and phylogeny based on high-quality SNPs were extracted from WGS data. XDR (86.1%), MDR (12.7%) and one PDR isolate from CC15 (1.3%) were identified. Colistin resistance was more frequent in CC25 isolates (P0.01). Prevalence of CC79 (n = 22; 27.8%) CC1 (n = 21; 26.6%), CC15 (n = 21; 26.6%) and CC25 (n = 12; 15.2%) was observed. Regarding carbapenem-hydrolysing class D β-lactamases (CHDLs), bla |
| Databáze: | OpenAIRE |
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