The medi-RIVAGE study (mediterranean diet, cardiovascular risks and gene polymorphisms): rationale, recruitment, design, dietary intervention and baseline characteristics of participants
| Autor: | Catherine Defoort, H Portugal, Irène Juhan-Vague, Marie-Jo Amiot-Carlin, M.C. Bernard, Mariette Gerber, Stephanie Vincent, P Charpiot, Richard Planells, Denis Lairon, A Loundou, P. Vague, Pascal Grolier |
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| Přispěvatelé: | ProdInra, Migration, Institut Méditerranéen de Biochimie et Biologie de la Nutrition (IMRN), Institut National de la Recherche Agronomique (INRA), Unité de nutrition et métabolisme protéique |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Homocysteine Mediterranean diet 030309 nutrition & dietetics Saturated fat [SDV]Life Sciences [q-bio] Medicine (miscellaneous) 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Risk factor ComputingMilieux_MISCELLANEOUS 2. Zero hunger 0303 health sciences Nutrition and Dietetics business.industry Cholesterol Public Health Environmental and Occupational Health Micronutrient medicine.disease 3. Good health [SDV] Life Sciences [q-bio] chemistry Metabolic syndrome business Body mass index |
| Zdroj: | Public Health Nutrition Public Health Nutrition, Cambridge University Press (CUP), 2004, 7 (4), pp.531-542 |
| ISSN: | 1368-9800 1475-2727 |
| Popis: | Objective:To report the rationale, recruitment, design, dietary intervention and baseline characteristics of participants in the Medi-RIVAGE study (Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms).Design:A randomised, parallel trial comparing a new nutritional programme with a conventional programme.Setting:Centre for Detection and Prevention of Arteriosclerosis, Timone University Hospital, Marseille, France, and collaborating teams.Subjects:Two hundred and twelve male and female volunteers with at least one cardiovascular risk factor.Intervention:A Mediterranean-type diet characterised mainly by the quality of fatty acids, amount of fish, vegetable foodstuffs and fibre was proposed and compared with a usually prescribed, low-fat/cholesterol diet. Body mass index, fasting lipids and lipoproteins, apolipoproteins, glucose, insulin and homocysteine were the main outcome measures. Gene polymorphisms of interest were determined.Results:Characteristics of men in the two arms were comparable with regard to sociodemographic variables, and clinical and biological cardiovascular risk factors. There were few differences between the groups of women (cholesterol-related parameters,P< 0.05). There was no difference between arms in allelic distribution of the gene polymorphisms studied. Saturated fat and protein intakes were high while carbohydrate and fibre intakes were low, but with no difference between arms. Overall, the nutritional markers were comparable in both arms with few exceptions. Correlations between nutritional intakes and plasma nutrient levels ranged from 0.19 (β-carotene) to 0.47 (folate).Conclusions:The comparability of the two arms is notable and warrants a low risk of biases. Current diet departs from the traditional Mediterranean one. The assessment of nutritional intake is validated by correlations obtained between dietary intake and relevant biomarkers. This will be important to estimate participant compliance and to analyse intervention data. |
| Databáze: | OpenAIRE |
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