Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units

Autor: Noordermeer, Tessa, Schutgens, Roger E. G., Visser, Chantal, Rademaker, Emma, de Maat, Moniek P. M., Jansen, A. J. Gerard, Limper, Maarten, Cremer, Olaf L., Kruip, Marieke J. H. A., Endeman, Henrik, Maas, Coen, de Laat, Bas, Urbanus, Rolf T., van de Beek, D., Brouwer, M. C., de Bruin, S., Coppens, M., van Es, N., van Haaps, T. F., Juffermans, N. P., Muller, M. C. A., Vlaar, A. P. J., Hertogh, C. M. P. M., Heunks, L. M. A., Hugtenburg, J. G., van Kooten, J., Nossent, E. J., Smulders, Y., Tuinman, P. R., Noordegraaf, A. Vonk, Grootenboers, M. J. J. H., van Guldener, C., Kant, M., Lansbergen, A., Faber, J., Hajer, G., Stemerdink, A., van den Akker, J., Bierings, R., Endeman, H., Goeijenbier, M., Hunfeld, N. G. M., van Gorp, E. C. M., Gommers, D. A. M. P. J., Koopmans, M. P. G., Kruip, M. J. H. A., Kuiken, T., Langerak, T., Leebeek, Lauw, M. N., de Maat, M. P. M., Noack, D., Paats, M. S., Raadsen, M. P., Rockx, B., Rokx, C., Schurink, C. A. M., Tong-Minh, K., van den Toorn, L., den Uil, C. A., Visser, C., Boutkourt, F., Roest, T., Douma, R. A., de Haan, L. R., ten Wolde, M., Bemelmans, R. H. H., Festen, B., Stads, S., de Jager, C. P. C., Simons, K. S., Antoni, M. L., Bos, M. H., Burggraaf, J. L. I., Cannegieter, S. C., Eikenboom, H. C. J., den Exter, P. L., Geelhoed, J. J. M., Huisman, M. V., de Jonge, E., Kaptein, F. H. J., Klok, F. A., Kroft, L. J. M., Lijfering, W. M., Nab, L., Ninaber, M. K., Putter, H., Ramai, S. R. S., da Rocha Rondon, A. M., Roukens, A. H. E., Stals, M. A. M., Versteeg, H. H., Vliegen, H. W., van Vlijmen, B. J. M., van de Berg, T., Bruggemann, R., van Bussel, B. C. T., ten Cate, H., ten Cate-Hoek, A., Hackeng, T. M., Henskens, ir. Y., Hulshof, A., Mulder, M., Olie, R. H., Schurgers, L., Spaetgens, B., Spronk, H., Spruit, M. A., Winckers, K., Nieuwenhuizen, L., Franken, B., Schrover, I. M., de Waal, E. G. M., Beishuizen, A., Cornet, A., Krabbe, J., Kramers, K., Leentjens, J., de Mast, Q., Middeldorp, S., Brouwer, R. E., Ellerbroek, J. L. J., Tijmensen, J., Hovens, M. M. C., Oostdijk, E. A. N., Westerhof, B. D., Faber, L. M., van den Biggelaar, M., Meijers, J. C. M., Voorberg, J., Kevenaar, M. E., Soei, Y. L., Wils, E. J., Croles, F. N., de Laat, B., Kamphuisen, P. W., Vink, R., Lisman, T., Meijer, K., van Tichelaar, Y. I. G., Cremer, O. L., Geersing, G., Kaasjager, H. A. H., Kusadasi, N., Huisman, A., Maas, C., Nijkeuter, M., Schutgens, R. E. G., Creveldkliniek, Van, Urbanus, R. T., Westerink, J., Faber, H. J., Koster, S. C. E., van Montfort, P., van Twist, D. J. L.
Přispěvatelé: RS: Carim - B01 Blood proteins & engineering, Biochemie, Hematology, Intensive Care, Neurology, ANS - Neuroinfection & -inflammation, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Graduate School, ACS - Microcirculation, Medical Microbiology and Infection Prevention, ARD - Amsterdam Reproduction and Development, Experimental Vascular Medicine, Landsteiner Laboratory, ACS - Atherosclerosis & ischemic syndromes, Elderly care medicine, APH - Aging & Later Life, Clinical pharmacology and pharmacy, APH - Health Behaviors & Chronic Diseases, Pulmonary medicine, Internal medicine, ACS - Diabetes & metabolism, Intensive care medicine, General practice, Amsterdam Gastroenterology Endocrinology Metabolism
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Research and practice in thrombosis and haemostasis, 6(6):12809. Wiley
Research and Practice in Thrombosis and Haemostasis, 6(6):e12809. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, 6, 6
Research and Practice in Thrombosis and Haemostasis, 6
Research and practice in thrombosis and haemostasis, 6(6):e12809. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, 6(6). WILEY
Noordermeer, T, Schutgens, R E G, Visser, C, Rademaker, E, de Maat, M P M, Jansen, A J G, Limper, M, Cremer, O L, Kruip, M J H A, Endeman, H, Maas, C, de Laat, B, Urbanus, R T, the Dutch COVID & Thrombosis Coalition (DCTC), van de Beek, D, Brouwer, M C, de Bruin, S, Coppens, M, van Es, N, van Haaps, T F, Juffermans, N P, Muller, M C A, Vlaar, A P J, Hertogh, C M P M, Heunks, L M A, Hugtenburg, J G, van Kooten, J, Nossent, E J, Smulders, Y, Tuinman, P R, Noordegraaf, A V, Grootenboers, M J J H, van Guldener, C, Kant, M, Lansbergen, A, Faber, J, Hajer, G, Stemerdink, A, van den Akker, J, Bierings, R, Endeman, H, Goeijenbier, M, Hunfeld, N G M, van Gorp, E C M, Gommers, D A M P J, Koopmans, M P G, Kruip, M J H A, Kuiken, T, Langerak, T, Leebeek, Lauw, M N, de Maat, M P M, Noack, D, Paats, M S, Raadsen, M P, Rockx, B, Rokx, C, Schurink, C A M, Tong-Minh, K, van den Toorn, L, den Uil, C A, Visser, C, Boutkourt, F, Roest, T, Douma, R A, de Haan, L R, ten Wolde, M, Bemelmans, R H H, Festen, B, Stads, S, de Jager, C P C, Simons, K S, Antoni, M L, Bos, M H, Burggraaf, J L I, Cannegieter, S C, Eikenboom, H C J, den Exter, P L, Geelhoed, J J M, Huisman, M V, de Jonge, E, Kaptein, F H J, Klok, F A, Kroft, L J M, Lijfering, W M, Nab, L, Ninaber, M K, Putter, H, Ramai, S R S, da Rocha Rondon, A M, Roukens, A H E, Stals, M A M, Versteeg, H H, Vliegen, H W, van Vlijmen, B J M, van de Berg, T, Bruggemann, R, van Bussel, B C T, ten Cate, H, ten Cate-Hoek, A, Hackeng, T M, Henskens, I Y, Hulshof, A, Mulder, M, Olie, R H, Schurgers, L, Spaetgens, B, Spronk, H, Spruit, M A, Winckers, K, Nieuwenhuizen, L, Franken, B, Schrover, I M, de Waal, E G M, Beishuizen, A, Cornet, A, Krabbe, J, Kramers, K, Leentjens, J, de Mast, Q, Middeldorp, S, Brouwer, R E, Ellerbroek, J L J, Tijmensen, J, Hovens, M M C, Oostdijk, E A N, Westerhof, B D, Faber, L M, van den Biggelaar, M, Meijers, J C M, Voorberg, J, Kevenaar, M E, Soei, Y L, Wils, E J, Croles, F N, de Laat, B, Kamphuisen, P W, Vink, R, Lisman, T, Meijer, K, van Tichelaar, Y I G, Cremer, O L, Geersing, G, Kaasjager, H A H, Kusadasi, N, Huisman, A, Maas, C, Nijkeuter, M, Schutgens, R E G, Creveldkliniek, V, Urbanus, R T, Creveldkliniek, V, Westerink, J, Faber, H J, Koster, S C E, van Montfort, P & van Twist, D J L 2022, ' Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units : A retrospective cohort study ', Research and practice in thrombosis and haemostasis, vol. 6, no. 6, e12809 . https://doi.org/10.1002/rth2.12809
ISSN: 2475-0379
Popis: Contains fulltext : 286889.pdf (Publisher’s version ) (Open Access) BACKGROUND: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear. OBJECTIVE: To investigate if LA is associated with thrombosis in critically ill patients with COVID-19. PATIENTS/METHODS: The presence of LA and other antiphospholipid antibodies was assessed in patients with COVID-19 admitted to the ICU. LA was determined with dilute Russell's viper venom time (dRVVT) and LA-sensitive activated partial thromboplastin time (aPTT) reagents. RESULTS: Of 169 patients with COVID-19, 116 (69%) tested positive for at least one antiphospholipid antibody upon admission to the ICU. Forty (24%) patients tested positive for LA; of whom 29 (17%) tested positive with a dRVVT, 19 (11%) tested positive with an LA-sensitive aPTT, and 8 (5%) tested positive on both tests. Fifty-eight (34%) patients developed thrombosis after ICU admission. The odds ratio (OR) for thrombosis in patients with LA based on a dRVVT was 2.5 (95% confidence interval [CI], 1.1-5.7), which increased to 4.5 (95% CI, 1.4-14.3) in patients at or below the median age in this study (64 years). LA positivity based on a dRVVT or LA-sensitive aPTT was only associated with thrombosis in patients aged less than 65 years (OR, 3.8; 95% CI, 1.3-11.4) and disappeared after adjustment for C-reactive protein. CONCLUSION: Lupus anticoagulant on admission is strongly associated with thrombosis in critically ill patients with COVID-19, especially in patients aged less than 65 years.
Databáze: OpenAIRE
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