The one microgram adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function
| Autor: | Giovanni Faglia, Bruno Ambrosi, T. Re, L. Barbetta, E. Passini |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Cortisol awakening response Endocrinology Diabetes and Metabolism medicine.medical_treatment Pituitary-Adrenal System Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Internal medicine Hypoadrenalism Blood plasma medicine Humans Insulin Aged Hydrocortisone Analysis of Variance business.industry Insulin tolerance test General Medicine Middle Aged Evaluation Studies as Topic Case-Control Studies Linear Models Female business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | European Journal of Endocrinology. 139:575-579 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1390575 |
| Popis: | The possibility of assessing hypothalamic-pituitary-adrenal (HPA) function by the standard ACTH test (250 microg) has been widely discussed in the past years and compared with the role of the insulin tolerance test (ITT). Recently, it was shown that low doses of ACTH, such as 1 microg i.v., induce a maximal adrenal response and, by reducing the discrepancies compared with the ITT also allow one to detect mild forms of secondary hypoadrenalism. In the present study the 1 microg ACTH test was performed in patients with hypothalamic-pituitary disease in order to assess adrenal function, and the results have been compared with those obtained after the insulin test. Fifty-seven patients (31 men and 26 women, aged 19-73 years) with hypothalamic-pituitary diseases were studied: 51 patients were affected with pituitary tumor and 6 patients had hypothalamic disorders. All these patients and 18 healthy volunteers (7 men and 11 women, aged 19-46 years) received 1 microg i.v. ACTH injection. In addition, the ITT (0.1-0.15 U/kg body weight) was performed in all patients. In normal subjects mean cortisol levels significantly (P |
| Databáze: | OpenAIRE |
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