Carotid intima-media thickness as a marker of cardiovascular risk in hypertensive patients with coronary artery disease
| Autor: | Jacek Kadziela, Tomasz Zieliński, Witold Rużyłło, Jerzy Korewicki, Zbigniew Juraszyński, Andrzej Januszewicz, Marek Naruszewicz, Zofia Dzielińska, Dariusz Rynkun, Magdalena Januszewicz, Marcin Demkow, Aleksander Prejbisz, Magdalena Makowiecka Ciesla, Pawel Tyczynski |
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| Rok vydání: | 2007 |
| Předmět: |
Tunica media
Adult Male medicine.medical_specialty Myocardial Infarction Coronary Artery Disease Kaplan-Meier Estimate Coronary artery disease Predictive Value of Tests Risk Factors Internal medicine Internal Medicine medicine Clinical endpoint Humans cardiovascular diseases Myocardial infarction Risk factor Stroke Aged Aged 80 and over Ultrasonography Doppler Duplex business.industry Middle Aged medicine.disease Prognosis Coronary arteries medicine.anatomical_structure Carotid Arteries Intima-media thickness Hypertension cardiovascular system Cardiology Female business Tunica Intima Tunica Media Biomarkers Follow-Up Studies |
| Zdroj: | American journal of hypertension. 20(10) |
| ISSN: | 0895-7061 |
| Popis: | The aim of this study was to examine the significance of ultrasound-measured carotid intima-media thickness (CIMT) in high-risk patients with hypertension and coronary artery disease (CAD), as an independent prognostic factor in determining the risk of all-cause death or future cardiovascular events.The study included 297 consecutive patients (mean age +/- SD, 57 +/- 9.4 years) with diagnosed hypertension and CAD, referred for coronary angiography. The mean of maximal CIMT in two arterial segments bilaterally was calculated. The primary endpoint was a patient's death from all causes. Death, stroke, or myocardial infarction comprised the secondary, composite endpoint.There was a follow-up of 1 to 79 (mean, 41) months. The predictors of death in a multivariate Cox proportional hazards model were the number of stenosed coronary arteries (P = .007) and CIMT (P = .001). The risk of the secondary, composite endpoint (death, stroke, or myocardial infarction) was determined by diabetes (P = .008) and CIMT (P = .010). Nearly 99% of patients with "low CIMT" (or =1.13 mm) survived for 5 years, versus 78% with "high CIMT"1.13 mm (log-rank test; P.001). For the secondary, composite endpoint (death, stroke, or myocardial infarction), the event-free survival rate was 95% (low CIMT), versus 74% after 5 years (high CIMT) (P.008).Intima-media thickness of the carotid arteries is a strong and independent predictor of death and serious cardiovascular events in hypertensive patients with CAD referred for coronary angiography. |
| Databáze: | OpenAIRE |
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