Comparison of Human Antral Follicles of Xenograft versus Ovarian Origin Reveals Disparate Molecular Signatures
| Autor: | Zev Rosenwaks, K. Hancock, Benjamin Schattman, Daylon James, Limor Man, Nikica Zaninovic, Eleni Kallinos, David Redmond, Glenn L. Schattman, Zachary Redhead-Laconte, Nicole Lustgarten-Guahmich, Sally Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cell type endocrine system Stromal cell fertility preservation Granulosa cell Ovary human folliculogenesis Biology General Biochemistry Genetics and Molecular Biology single-cell RNA sequencing Mice 03 medical and health sciences 0302 clinical medicine Ovarian Follicle medicine ovarian tissue transplantation Animals Humans lcsh:QH301-705.5 ovarian tissue xenograft Theca Cell Antral follicle Xenograft Model Antitumor Assays Cell biology Disease Models Animal 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Theca Female Folliculogenesis antral follicle 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol 32, Iss 6, Pp 108027-(2020) |
| ISSN: | 2211-1247 |
| Popis: | Summary: The activation, growth, and maturation of oocytes to an ovulatory phase, termed folliculogenesis, is governed by the orchestrated activity of multiple specialized cell types within the ovary; yet, the mechanisms governing diversification and behavior of discrete cellular sub-populations within follicles are poorly understood. We use bulk and single-cell RNA sequencing to distinguish the transcriptional signature of prospectively isolated granulosa and theca/stroma cell subsets within human antral follicles derived from xenografts or ovaries. The analysis deconstructs phenotypic diversification within small ( |
| Databáze: | OpenAIRE |
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