Synthesis and Skeletal Muscle Relaxant Activity of Quaternary Ammonium Salts of Dantrolene and Clodanolene
| Autor: | F. L. Wessels, George C. Wright, K. O. Ellis, Ralph L. White |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Chemical Phenomena medicine.drug_class Pharmaceutical Science Pharmacology Dantrolene Lethal Dose 50 Mice chemistry.chemical_compound Aqueous solubility Clodanolene medicine Animals Ammonium Furans Postural Balance Behavior Animal Muscle Relaxants Central Chemistry Muscles Imidazoles Antagonist Skeletal muscle Muscle relaxant Rats Sodium salt Quaternary Ammonium Compounds medicine.anatomical_structure Biochemistry Injections Intravenous medicine.drug |
| Zdroj: | Journal of Pharmaceutical Sciences. 69:327-331 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600690319 |
| Popis: | A series of quaternary ammonium salts of dantrolene and clodanolene was prepared and evaluated for skeletal muscle relaxant activity. The quaternary ammonium salts exhibit greater aqueous solubility and, therefore, facilitate intravenous administration. One member of this series, although less effective orally, exhibited greater aqueous solubility than the sodium salt. When administered intravenously, it was a more potent antagonist of skeletal muscle contraction and yielded comparable therapeutic and muscle relaxant efficacy indexes. |
| Databáze: | OpenAIRE |
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