Epigenetic mechanisms underlying lifespan and age-related effects of dietary restriction and the ketogenic diet
| Autor: | Charles V. Mobbs, Cesar L. Moreno |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.medical_treatment Longevity Hypothalamus Context (language use) Biology Biochemistry Histone Deacetylases Epigenesis Genetic Histones 03 medical and health sciences Endocrinology Sirtuin 1 Internal medicine Age related Hydroxybenzoates medicine HDAC inhibitor Animals Humans Epigenetics Molecular Biology Caloric Restriction Neurons Neurodegeneration DNA Methylation medicine.disease CREB-Binding Protein Histone Deacetylase Inhibitors 030104 developmental biology Sirtuin biology.protein Diet Ketogenic Neuroscience Signal Transduction Ketogenic diet |
| Zdroj: | Molecular and Cellular Endocrinology. 455:33-40 |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2016.11.013 |
| Popis: | Aging constitutes the central risk factor for major diseases including many forms of cancer, neurodegeneration, and cardiovascular diseases. The aging process is characterized by both global and tissue-specific changes in gene expression across taxonomically diverse species. While aging has historically been thought to entail cell-autonomous, even stochastic changes, recent evidence suggests that modulation of this process can be hierarchal, wherein manipulations of nutrient-sensing neurons (e.g., in the hypothalamus) produce peripheral effects that may modulate the aging process itself. The most robust intervention extending lifespan, plausibly impinging on the aging process, involves different modalities of dietary restriction (DR). Lifespan extension by DR is associated with broad protection against diseases (natural and engineered). Here we review potential epigenetic processes that may link lifespan to age-related diseases, particularly in the context of DR and (other) ketogenic diets, focusing on brain and hypothalamic mechanisms. |
| Databáze: | OpenAIRE |
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