Vitamin D receptor gene polymorphism in children with urinary tract infection
| Autor: | Beyhan Cengiz Özyurt, Ferda Ozkinay, Hüseyin Onay, Sule Aslan, Ipek Akil, Gulcin Itirli Aslan |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2011 |
| Předmět: |
Nephrology
Male medicine.medical_specialty TaqI Genotype Urinary system Renal scar urologic and male genital diseases Gastroenterology Calcitriol receptor chemistry.chemical_compound Polymorphism (computer science) Internal medicine Cystitis medicine Vitamin D and neurology Humans Child Vitamin D receptor gene polymorphism Urinary tract infection Polymorphism Genetic biology Pyelonephritis business.industry FokI Endocrinology chemistry Child Preschool Pediatrics Perinatology and Child Health Urinary Tract Infections biology.protein Receptors Calcitriol Female business |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 27(3) |
| ISSN: | 1432-198X |
| Popis: | WOS: 000299506100011 PubMed ID: 21947233 It is known that small alterations leading to different vitamin D receptor (VDR) alleles affect resistance or susceptibility to infections. In this study, we examined VDR gene polymorphisms in urinary tract infections (UTI), which are common and an important cause of morbidity in children and subsequently of renal scar formation. We evaluated 92 patients diagnosed with UTI and 105 children without prior history of UTI as a control group. The VDR gene polymorphisms BsmI, FokI, ApaI, and TaqI were evaluated in patients and controls. BsmI polymorphism genotype distribution was similar between groups. There was a significant difference between groups for FokI (p = 0 < 001); for the ff genotype, the risk of UTI was significantly increased (p < 0.01) ,at 3.94 times higher (odds ratio = 3.94; 95% confidence interval 1.71-9.09). ApaI polymorphism was significantly increased in the control group (p < 0.01) and evaluated as a protective factor. Comparing the TaqI genotype between groups, there was no statistically significant difference, but in both Tt and tt genotypes, there was minimal increased risk of UTI. The results of this study suggest that VDR gene polymorphisms can be important for susceptibility to UTI and renal scar formation. Association between VDR polymorphisms and UTI is in accordance with the understanding of how vitamin D modulates the immune response against infections. |
| Databáze: | OpenAIRE |
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