Treatment-resistant actinic keratoses are characterized by distinct clinical and histological features
| Autor: | Markus V. Heppt, Conrad Falkenberg, Lutz Schmitz, Josep Malvehy, Theresa Steeb, Amrei Brehmer, Thilo Gambichler, Thomas Dirschka, G. Gupta |
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| Rok vydání: | 2021 |
| Předmět: |
Sebaceous gland
Keratinocytes medicine.medical_specialty Skin Neoplasms medicine.diagnostic_test business.industry Acantholysis Biopsy Hyperkeratosis Dermatology Actinic keratoses medicine.disease Palpation Keratosis Actinic Basal (phylogenetics) Infectious Diseases medicine.anatomical_structure Follicular phase medicine Carcinoma Squamous Cell Humans business Grading (tumors) |
| Zdroj: | Italian journal of dermatology and venereology. 156(2) |
| ISSN: | 2784-8450 |
| Popis: | BACKGROUND Actinic keratoses (AK) are generally treated to reduce the risk of progression into invasive cutaneous squamous cell carcinoma (cSCC). However, this risk of transformation is low, and rather than focusing on these lesions, current treatment studies report on complete clearance of AKs in an entire field. This study aimed to investigate treatment-resistant AKs (trAK) after field therapy compared to randomly chosen AKs prior to treatment. METHODS AKs were clinically assessed according to the grade of hyperkeratosis and pain on palpation, prior to treatment. TrAKs were biopsied and compared to AKs which were biopsied prior to any treatment. AKs were evaluated regarding histological severity (AKI-III), their basal growth grading (PROI-III), acantholysis, elastosis, follicular extension of atypical keratinocytes and accompanying infiltrate. RESULTS Two hundred eleven AKs in 171 patients were identified. TrAKs (N.=79) were significantly more painful (64.6% vs. 22.0%; P |
| Databáze: | OpenAIRE |
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