Photodynamic inactivation of pathogenic Gram-negative and Gram-positive bacteria mediated by Si(IV) phthalocyanines bearing axial ammonium units

Autor:	Sara R.D. Gamelas, Cátia Vieira, Maria Bartolomeu, Maria A.F. Faustino, João P.C. Tomé, Augusto C. Tomé, Adelaide Almeida, Leandro M.O. Lourenço
Rok vydání:	2022
Předmět:	Staphylococcus aureus Radiation Indoles Photosensitizing Agents Porphyrins Radiological and Ultrasound Technology Biophysics Gram-Positive Bacteria Anti-Bacterial Agents Photochemotherapy Ammonium Compounds Gram-Negative Bacteria Escherichia coli Radiology Nuclear Medicine and imaging
Zdroj:	Journal of photochemistry and photobiology. B, Biology. 233
ISSN:	1873-2682
Popis:	The photodynamic inactivation (PDI) of microorganisms has gained interest as an efficient option for conventional antibiotic treatments. Recently, Si(IV) phthalocyanines (SiPcs) have been highlighted as promising photosensitizers (PSs) to the PDI of microorganisms due to their remarkable absorption and emission features. To increase the potential of cationic SiPcs as PS drugs, one novel (1a) and two previously described (2a and 3a) axially substituted PSs with di-, tetra-, and hexa-ammonium units, respectively, were synthesized and characterized. Their PDI effect was evaluated for the first time against Escherichia coli and Staphylococcus aureus, a Gram-negative and a Gram-positive bacterium, respectively. The photodynamic treatments were conducted with PS concentrations of 3.0 and 6.0 μM under 60 min of white light irradiation (150 mW.cm
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55790c8e67aa5040337f160ed4225df https://pubmed.ncbi.nlm.nih.gov/35759946 Zobrazit plný text záznamu Full Text from ScienceDirect