Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication
| Autor: | Yoichi Sugita, Koujiro Tohyama, Tsutomu Hashikawa, Tsuyako Hayashida, Wan Zhu Bai, Norio Hirano, Yan-Chao Li, Takahide Taniguchi |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Central Nervous System
Male Swine viruses Encephalomyelitis Central nervous system Coated Vesicles coronavirus Coated vesicle Biology medicine.disease_cause Virus transsynaptic transfer Viral Matrix Proteins medicine Animals Rats Wistar Research Articles virus replication Cell Line Transformed Coronavirus Neurons Neurotropic virus Viral matrix protein General Neuroscience medicine.disease Virology Rats Disease Models Animal Protein Transport medicine.anatomical_structure Viral replication Synapses Coronavirus Infections Research Article |
| Zdroj: | The Journal of Comparative Neurology |
| ISSN: | 0021-9967 |
| DOI: | 10.1002/cne.23171 |
| Popis: | Swine hemagglutinating encephalomyelitis virus (HEV) has been shown to have a capability to propagate via neural circuits to the central nervous system after peripheral inoculation, resulting in acute deadly encephalomyelitis in natural host piglets as well as in experimental younger rodents. This study has systematically examined the assembly and dissemination of HEV 67N in the primary motor cortex of infected rats and provides additional evidence indicating that membranous‐coating‐mediated endo‐/exocytosis can be used by HEV for its transsynaptic transfer. In addition, our results suggested that this transsynaptic pathway could adapted for larger granular materials, such as viruses. These findings should help in understanding the mechanisms underlying coronavirus infections as well as the intercellular exchanges occurring at the synaptic junctions. J. Comp. Neurol. 521:203–212, 2013. © 2012 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text