Comparative evaluation of cytokines in gingival crevicular fluid and saliva of patients with aggressive periodontitis
| Autor: | Elizabeth L Y Ng, Guo Wen, Louis W.C. Chow, Lan-jun Bai, Mary N.B. Cheung, Yi-ding Dou, Yuan Yue, Ye Tian, Liang Hao, Chunjiao Xu, Qing Liu, Adrian Y S Yip, Wings T.Y. Loo, Min Wang, Jin-le Li |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Saliva Clinical Biochemistry Treatment outcome Gastroenterology Pathology and Forensic Medicine Comparative evaluation Crevicular fluid 03 medical and health sciences Young Adult 0302 clinical medicine Cytokines metabolism Internal medicine medicine Aggressive periodontitis Humans Young adult business.industry Case-control study 030206 dentistry Gingival Crevicular Fluid medicine.disease Treatment Outcome Oncology 030220 oncology & carcinogenesis Case-Control Studies Chronic Periodontitis Cytokines Female business Biomarkers |
| Zdroj: | The International journal of biological markers. 28(1) |
| ISSN: | 1724-6008 |
| Popis: | Objectives This study aims to evaluate and compare cytokines in gingival crevicular fluid (GCF) and saliva of patients with aggressive periodontitis (AP) before and after treatment. Methods Forty AP patients and 40 healthy volunteers were enrolled in this study. Clinical parameters included probing depth and sulcus bleeding index. GCF and saliva were collected from both groups. The levels of IL-1β, IL-2, IL-4, IL-6, IFN-γ and TNF-α were measured using ELISA. Results The probing depth in AP patients was significantly deeper before treatment than after treatment. The concentrations of cytokines in GCF and saliva were significantly higher in AP patients than in the control group and decreased after periodontal treatment. Positive relationships were found between cytokine levels in GCF and clinical parameters. The reliability of cytokines in GCF and saliva was assessed by Cronbach's alpha analysis, which could be considered satisfactory. Conclusion Cytokine levels in GCF and saliva correlated well with clinical parameters and AP. Measurements of cytokines in saliva may be regarded as a noninvasive and quick method for monitoring periodontal disease activity. |
| Databáze: | OpenAIRE |
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