Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection
| Autor: | Dayna R. Clark, Sing Sing Way, Lijun Xin, Jeremy M. Kinder, James M. Ertelt, Tony T. Jiang, Chaturvedi |
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| Rok vydání: | 2015 |
| Předmět: |
Lipopolysaccharides
LPS Lipopolysaccharide Neutrophils Immunology Article antibiotics Microbiology Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Enterobacteriaceae Antigen Immunity Candida albicans Animals Antigens Ly Immunology and Allergy Pathogen Candida Disease Resistance 0303 health sciences biology commensal bacteria 030306 microbiology Host (biology) Candidiasis biochemical phenomena metabolism and nutrition biology.organism_classification infection Immunity Innate Corpus albicans Anti-Bacterial Agents 3. Good health Disease Models Animal Phenotype Neutrophil Infiltration chemistry Host-Pathogen Interactions Microbial Interactions 030215 immunology |
| Zdroj: | Mucosal immunology Mucosal Immunology |
| ISSN: | 1933-0219 |
| Popis: | Commensal enteric bacteria maintain systemic immune responsiveness that protects against disseminated or localized infection in extra-intestinal tissues caused by pathogenic microbes. However, as shifts in infection susceptibility after commensal bacteria eradication have primarily been probed using viruses, the broader applicability to other pathogen types remains undefined. In sharp contrast to diminished antiviral immunity, we show commensal bacteria eradication bolsters protection against disseminated Candida albicans fungal infection. Enhanced antifungal immunity reflects more robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, and their mobilization into infected tissues among antibiotic-treated compared with commensal bacteria-replete control mice. Reciprocally, depletion of neutrophils from expanded levels or intestinal lipopolysaccharide reconstitution overrides the antifungal protective benefits conferred by commensal bacteria eradication. This discordance in antifungal compared with antiviral immunity highlights intrinsic differences in how commensal bacteria control responsiveness for specific immune cell subsets, because pathogen-specific CD8(+) T cells that protect against viruses were suppressed similarly after C. albicans and influenza A virus infection. Thus, positive calibration of antiviral immunity by commensal bacteria is counterbalanced by restrained activation of other immune components that confer antifungal immunity. |
| Databáze: | OpenAIRE |
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