Urinary neutrophil gelatinase-associated lipocalin and L-type fatty acid binding protein as diagnostic markers of early acute kidney injury after liver transplantation

Autor:	Qiang Xia, Bengt Lindholm, Miaolin Che, Zhaohui Ni, Qingwei Wu, Yi Li, Jiaqi Qian, Jonas Axelsson, Huili Dai, Yucheng Yan, Si-Yue Wang, Mingli Zhu, Renhua Lu
Rok vydání:	2012
Předmět:	Adult Male Pathology medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Urinary system Clinical Biochemistry Liver transplantation Lipocalin medicine.disease_cause Fatty Acid-Binding Proteins Biochemistry Gastroenterology Fatty acid-binding protein End Stage Liver Disease Lipocalin-2 Internal medicine Proto-Oncogene Proteins medicine Humans Postoperative Period Prospective Studies Prospective cohort study business.industry Acute kidney injury Diagnostic marker Acute Kidney Injury Middle Aged medicine.disease Lipocalins Liver Transplantation ROC Curve Area Under Curve Creatinine Female business Oxidative stress Biomarkers Acute-Phase Proteins
Zdroj:	Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 17(4)
ISSN:	1366-5804
Popis:	We examined the value of two potential novel urinary biomarkers, neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid binding protein (L-FABP), in diagnosing acute kidney injury (AKI) in liver transplant recipients.NGAL and L-FABP in urinary sample from Twenty-five patients before surgery and at 2, 4, 6, 12, 24, 48, 72 and 120 h after the anhepatic phase were tested. Standard statistics were used along with receiver-operating characteristic (ROC) analysis to evaluate the diagnostic value of selected markers.Urinary NGAL was only slightly elevated at 2 h in the non-AKI group while rose and stayed high from 2-6 h in the AKI group. However, urinary L-FABP rose transiently in both groups 2-120 h following surgery. The level of urinary NGAL presented differences at 2-6 h (p0.05) and urinary L-FABP at 4 h (p0.05) between AKI and non-AKI groups. ROC analysis showed that area under the curves (AUCs) of NGAL were 0.766, 0.773, and 0.773 at 2, 4 and 6 h respectively while 0.760 of L-FABP at 4 h.Urinary NGAL rather than L-FABP appeared to be a sensitive and specific marker of AKI in liver transplant recipients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e551087088f57ff03dacfa80d00e19c7 https://pubmed.ncbi.nlm.nih.gov/32274940 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.