Nanoparticles prepared from porous silicon nanowires for bio-imaging and sonodynamic therapy
| Autor: | Vladimir Sivakov, Veronika A. Georgobiani, A. A. Kudryavtsev, Florian Talkenberg, Victor Yu. Timoshenko, Ulyana А Natashina, V. V. Solovyev, Grigory A Mysov, Liubov A. Osminkina |
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| Rok vydání: | 2014 |
| Předmět: |
inorganic chemicals
Materials science Photoluminescence Nano Express Silicon Cytotoxicity technology industry and agriculture Nanowire Bio-imaging Nanochemistry chemistry.chemical_element Nanoparticle Nanotechnology Condensed Matter Physics Porous silicon Isotropic etching Sonodynamic therapy Silicon nanoparticles Silicon nanowires Theranostic Materials Science(all) chemistry General Materials Science Crystalline silicon |
| Zdroj: | Nanoscale Research Letters |
| ISSN: | 1556-276X |
| Popis: | Evaluation of cytotoxicity, photoluminescence, bio-imaging, and sonosensitizing properties of silicon nanoparticles (SiNPs) prepared by ultrasound grinding of porous silicon nanowires (SiNWs) have been investigated. SiNWs were formed by metal (silver)-assisted wet chemical etching of heavily boron-doped (100)-oriented single crystalline silicon wafers. The prepared SiNWs and aqueous suspensions of SiNPs exhibit efficient room temperature photoluminescence (PL) in the spectral region of 600 to 1,000 nm that is explained by the radiative recombination of excitons confined in small silicon nanocrystals, from which SiNWs and SiNPs consist of. On the one hand, in vitro studies have demonstrated low cytotoxicity of SiNPs and possibilities of their bio-imaging applications. On the other hand, it has been found that SiNPs can act as efficient sensitizers of ultrasound-induced suppression of the viability of Hep-2 cancer cells. |
| Databáze: | OpenAIRE |
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