Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice
| Autor: | Martha N. Havenith, Kerli Tulva, Jeffrey C. Glennon, Christian F. Beckmann, Sabrina van Heukelum, Sanne van Dulm, Arthur S. C. França, Jan K. Buitelaar, Brent A. Vogt, Femke E. Geers |
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| Rok vydání: | 2021 |
| Předmět: |
Neuroinformatics
Cingulate cortex medicine.medical_specialty Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Neurosciences. Biological psychiatry. Neuropsychiatry Biology cingulate cortex Article 03 medical and health sciences 0302 clinical medicine 130 000 Cognitive Neurology & Memory Internal medicine medicine resident-intruder test Pathological 030304 developmental biology 0303 health sciences Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] Microglia Aggression General Neuroscience aggression 220 Statistical Imaging Neuroscience food and beverages medicine.disease Astrogliosis cFos medicine.anatomical_structure Endocrinology astrogliosis Immunohistochemistry Neuron medicine.symptom Neuron death neuronal degeneration 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Brain Sciences Volume 11 Issue 7 Brain Sciences, Vol 11, Iss 868, p 868 (2021) Brain Sciences, 11, 7, pp. 1-13 Brain Sciences, 11, 1-13 |
| ISSN: | 2076-3425 |
| Popis: | Contains fulltext : 237700.pdf (Publisher’s version ) (Open Access) Pathological aggression is a debilitating feature of many neuropsychiatric disorders, and cingulate cortex is one of the brain areas centrally implicated in its control. Here we explore the specific role of midcingulate cortex (MCC) in the development of pathological aggression. To this end, we investigated the structural and functional degeneration of MCC in the BALB/cJ strain, a mouse model for pathological aggression. Compared to control animals from the BALB/cByJ strain, BALB/cJ mice expressed consistently heightened levels of aggression, as assessed by the resident-intruder test. At the same time, immunohistochemistry demonstrated stark structural degradation in the MCC of aggressive BALB/cJ mice: Decreased neuron density and widespread neuron death were accompanied by increased microglia and astroglia concentrations and reactive astrogliosis. cFos staining indicated that this degradation had functional consequences: MCC activity did not differ between BALB/cJ and BALB/cByJ mice at baseline, but unlike BALB/cByJ mice, BALB/cJ mice failed to activate MCC during resident-intruder encounters. This suggests that structural and functional impairments of MCC, triggered by neuronal degeneration, may be one of the drivers of pathological aggression in mice, highlighting MCC as a potential key area for pathologies of aggression in humans. |
| Databáze: | OpenAIRE |
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