Mesalazine-induced lung injury with severe respiratory failure successfully treated with steroids and non-invasive positive pressure ventilation

Autor: Tomoki Kimura, Atsushi Suzuki, Hajime Oi, Yasuhiko Yamano, Kensuke Kataoka, Toshiki Yokoyama, Toshiaki Matsuda, Yasuhiro Kondoh, Yasuhiko Suzuki
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Pulmonary and Respiratory Medicine
Case Report
PEEP
positive end-expiratory pressure

Lung injury
NPPV
non-invasive positive pressure ventilation

03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Mesalazine
CRP
c-reactive protein

BALF
bronchoalveolar lavage fluid

PaO2
partial pressure of oxygen

Medicine
Positive pressure ventilation
PaCO2
partial pressure of carbon dioxide

ARDS
acute respiratory distress syndrome

lcsh:RC705-779
TBLB
transbronchial lung biopsy

business.industry
Non invasive
lcsh:Diseases of the respiratory system
medicine.disease
Ulcerative colitis
SP-D
surfactant protein-D

Discontinuation
DLI
drug-induced lung injury

KL-6
Krebs von den Lungen-6

CT
computed tomography

UC
ulcerative colitis

030228 respiratory system
chemistry
Respiratory failure
5-ASA
5-aminosalicylic acid

030220 oncology & carcinogenesis
Anesthesia
Breathing
BAL
bronchoalveolar lavage

business
WBC
white blood cell
Zdroj: Respiratory Medicine Case Reports
Respiratory Medicine Case Reports, Vol 31, Iss, Pp 101157-(2020)
ISSN: 2213-0071
Popis: Drug-induced lung injury (DLI) has become more common because of the increasing number of therapeutic agents in use. Mesalazine, also known as 5-aminosalicylic acid (5-ASA), is one of the key drugs for the treatment of ulcerative colitis (UC). Although mesalazine-induced lung injury has been previously reported, few cases have included severe respiratory failure. In this report, we present a case of mesalazine-induced lung injury with severe respiratory failure, which was improved by discontinuation of mesalazine and introduction of corticosteroid therapy and ventilation support with non-invasive positive pressure ventilation (NPPV). We also review the previous literature on mesalazine-induced lung injury.
Databáze: OpenAIRE