Sebo-pharmacokinetics: a proposed percutaneous sebum egression method
| Autor: | John Havens Cary, Rasika Reddy, Howard I. Maibach, Akram Elmahdy |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Sebaceous gland medicine.medical_specialty Percutaneous Administration Topical Dermatology Sebaceous Glands 030207 dermatology & venereal diseases 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Pharmacokinetics Cricetinae Animals Humans Medicine Isotretinoin Acne 030203 arthritis & rheumatology business.industry medicine.disease Sebum Search terms medicine.anatomical_structure Pharmacodynamics business medicine.drug |
| Zdroj: | Journal of Dermatological Treatment. 30:189-193 |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546634.2018.1476648 |
| Popis: | Background/aims The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gland. A percutaneous egression method presents a way to study how drugs reaching the bloodstream can enter the skin. Methods A literature search was performed across databases (PubMed, Embase, and Google Scholar) and the University of California, San Francisco (UCSF) textbook library with relevant search terms. Results This search failed to reveal data on sebo-pharmacokinetics (PK); however, many articles center on pharmacodynamics (PD) - i.e. functional improvement instigated by oral or topical treatments. Experiments on humans and hamsters - representative sebaceous gland models - demonstrate indirect PD measures of sebaceous gland function. Discussion Here, we summarize the current available data on drug delivery via the sebaceous gland and suggest a practical method to directly document sebo-PK in man and animal. |
| Databáze: | OpenAIRE |
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