The Effect of GH Administration on Oocyte and Zygote Quality in Young Women With Repeated Implantation Failure After IVF
| Autor: | Maribel Galán-Lázaro, Cristina Conde-López, Jan Tesarik, Agnese M Chiara-Rapisarda, Raquel Mendoza-Tesarik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Pregnancy Rate Zygote Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Fertilization in Vitro lcsh:Diseases of the endocrine glands. Clinical endocrinology Andrology 03 medical and health sciences 0302 clinical medicine Implantation failure Endocrinology Ovulation Induction Pregnancy growth hormome Medicine Humans Embryo Implantation Birth Rate implantation rate Original Research Retrospective Studies In vitro fertilisation lcsh:RC648-665 business.industry Human Growth Hormone Embryo Retrospective cohort study Oocyte Embryo Transfer live birth rate 030104 developmental biology medicine.anatomical_structure embryonic structures Oocytes embryo quality Female oocyte quality business Live birth Live Birth Embryo quality |
| Zdroj: | Frontiers in Endocrinology, Vol 11 (2020) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| Popis: | Growth hormone (GH) has been shown to improve implantation and live birth rates in women of >40 years of age treated by in vitro fertilization (IVF). This effect was initially attributed to a GH effect on oocyte quality, but later studies showed that GH can also improve uterine receptivity for embryo implantation. As to younger women with previous failures of embryo implantation after IVF, data reported in the literature are ambiguous. This retrospective study focused on this latter category of women, comparing the numbers and morphological appearance of oocytes recovered from women with two previous IVF failures, aged between 30 and 39 years and treated with GH, with a comparable group of women without GH treatment. These results were complemented with the analysis of morphological markers of zygote and embryo quality and IVF clinical outcomes in both groups. The oocytes, zygotes and embryos from women treated with GH showed better morphological scores, and their uterine transfer resulted in more implantations, pregnancies and live births, as compared with the untreated group. It is concluded that the improvement of IVF outcomes in women with previous repeated IVF failures by exogenous GH administration is, at least partly, related to an increase in oocyte developmental potential. The statistically evident improvement of oocyte and embryo quality is the main finding of this study. Its weakness is its retrospective nature. |
| Databáze: | OpenAIRE |
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