Enzymatic Hydrolysis of Atracurium In Vivo
| Autor: | Melissa Auen, Aron Wajskol, Vladimir Nigrovic |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Tubocurarine Succinylcholine Carboxylesterase chemistry.chemical_compound Hydrolysis In vivo Enzymatic hydrolysis Animals Medicine chemistry.chemical_classification business.industry Skeletal muscle Rats Inbred Strains Isoquinolines Phosphate Rats Tritolyl Phosphates Anesthesiology and Pain Medicine medicine.anatomical_structure Enzyme chemistry Biochemistry Atracurium Hofmann elimination Neuromuscular Blocking Agents business Carboxylic Ester Hydrolases Muscle Contraction |
| Zdroj: | Anesthesiology. 62:606-609 |
| ISSN: | 0003-3022 |
| DOI: | 10.1097/00000542-198505000-00011 |
| Popis: | Inactivation of atracurium in vivo has been postulated to proceed along two pathways: Hofmann elimination and ester hydrolysis. Since an end product of Hofmann elimination (acrylate) may be potentially toxic, the authors conducted a study to determine the extent of degradation via enzyme catalyzed hydrolysis relative to that via Hofmann elimination. The enzyme carboxylesterase was inhibited by the pretreatment of rats with an organophosphorous compound, triorchotolyl phosphate (TOTP). Skeletal muscle relaxation produced either by d-tubocurarine or succinylcholine was not influenced by the pretreatment. This indicates that TOTP does not alter directly the paralyzing properties of either depolarizing or nondepolarizing muscle relaxants. Relaxation produced by atracurium, however, was prolonged markedly and the rate of recovery from relaxation was decreased. The authors conclude: 1) enzyme-catalyzed hydrolysis is probably responsible for the short duration of action of atracurium; 2) Hofmann elimination, at least in rats, probably is not the principal degradation pathway; and 3) the opportunity for in vivo generation of large amounts of po tentially toxic end products is less than previously implied. |
| Databáze: | OpenAIRE |
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