| Autor: |
Pierre-François, Meyer, Nicholas J, Ashton, Thomas K, Karikari, Cherie, Strikwerda-Brown, Theresa, Köbe, Julie, Gonneaud, Alexa, Pichet Binette, Hazal, Ozlen, Yara, Yakoub, Joel, Simrén, Josef, Pannee, Juan, Lantero-Rodriguez, Anne, Labonté, Suzanne L, Baker, Michael, Schöll, Eugeen, Vanmechelen, John C S, Breitner, Henrik, Zetterberg, Kaj, Blennow, Judes, Poirier, Sylvia, Villeneuve |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Annals of neurologyReferences. 91(4) |
| ISSN: |
1531-8249 |
| Popis: |
The objective of this study was to evaluate novel plasma p-tau231 and p-tau181, as well as AβIn a cohort of 244 older adults at risk of Alzheimer's disease (AD) owing to a family history of AD dementia, we measured single molecule array (Simoa)-based plasma tau biomarkers (p-tau231 and p-tau181), AβPlasma p-tau biomarkers correlated with flortaucipir binding in medial temporal, parietal, and inferior temporal regions. P-tau231 showed further associations in lateral parietal and occipital cortices. Plasma AβPlasma p-tau231 showed more robust associations with PET biomarkers than p-tau181 in presymptomatic individuals. The combination of p-tau and Aβ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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