Correction: Metal complexes as a promising source for new antibiotics
| Autor: | Feng Chen, Anna K. Renfrew, Alysha G. Elliott, Nicole Jung, Peter J. Rutledge, Murray V. Baker, Peter J. Sadler, Stefan Braese, Johannes Zuegg, Justin J. Wilson, Ahmed M. Mansour, Massimiliano Massi, Angelo Frei, A. Paden King, Gilles Dujardin, Mark E. Cooper, Charlotte E. Willans, John Moat, Christopher G. Dowson, Mark A. T. Blaskovich, Matthew H. Todd, Heba A. Mohamed, Christopher L. Brown |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Chemical Science Chemical science, 11 (17), 4531 |
| ISSN: | 2041-6520 2041-6539 |
| Popis: | There is a dire need for new antimicrobial compounds to combat the growing threat of widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of derivatives of known antibiotics, new classes of antibiotics are urgently required. Metal complexes are currently in clinical development for the treatment of cancer, malaria and neurodegenerative diseases. However, only little attention has been paid to their application as potential antimicrobial compounds. We report the evaluation of 906 metal-containing compounds that have been screened by the Community for Open Antimicrobial Drug Discovery (CO-ADD) for antimicrobial activity. Metal-bearing compounds display a significantly higher hit-rate (9.9%) when compared to the purely organic molecules (0.87%) in the CO-ADD database. Out of 906 compounds, 88 show activity against at least one of the tested strains, including fungi, while not displaying any cytotoxicity against mammalian cell lines or haemolytic properties. Herein, we highlight the structures of the 30 compounds with activity against Gram-positive and/or Gram-negative bacteria containing Mn, Co, Zn, Ru, Ag, Eu, Ir and Pt, with activities down to the nanomolar range against methicillin resistant |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|