Comparing the clinical application values of the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) in patients with ulcerative colitis
| Autor: | Shao-Jun Wang, Jing Guo, Zibin Tian, Hao Chen, Sheng-Bo Jin, Peng Li, Xueli Ding, Xiao-Fei Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Degree of Ulcerative Colitis Burden of Luminal Inflammation score business.industry Gastroenterology Inflammation Original Articles medicine.disease Ulcerative colitis Degree (temperature) Mayo Endoscopic Subscore 03 medical and health sciences 0302 clinical medicine Ulcerative Colitis Endoscopic Index of Severity 030220 oncology & carcinogenesis Internal medicine medicine 030211 gastroenterology & hepatology In patient medicine.symptom business AcademicSubjects/MED00260 ulcerative colitis |
| Zdroj: | Gastroenterology Report |
| ISSN: | 2052-0034 |
| DOI: | 10.1093/gastro/goab026 |
| Popis: | Background The significance of endoscopic evaluation in the diagnosis and management of ulcerative colitis (UC) has been widely recognized. Over the years, scholars have established several endoscopic scores. Herein, we assessed the clinical application value of the Mayo Endoscopic Subscore (Mayo ES), the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score, and the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score in UC patients, by comparing their correlation with disease activity and their predictive potential for treatment response and clinical outcomes. Methods UC patients hospitalized from September 2015 to September 2019 were retrospectively analysed. We employed Spearman's rank correlation coefficient to assess the linear association of the assessed endoscopic scores with the clinical parameters. The receiver-operating characteristic curve was applied to evaluate the predictive capabilities of the endoscopic scores for treatment escalation and 1-year readmission. Results A total of 178 patients were enrolled; most of them (82%) suffered moderate or severe colitis. Among them, 48 (27%) patients received treatment escalation and 59 (33%) were readmitted within 1 year. The DUBLIN and UCEIS scores demonstrated higher correlations with clinical parameters than the Mayo ES. The DUBLIN scores significantly differed between patients with mild, moderate, and severe colitis (all P 0.05). Conclusion This study demonstrates that both the DUBLIN and UCEIS scores outperform the Mayo ES in assessing disease severity and predicting treatment response and clinical outcomes in UC patients. |
| Databáze: | OpenAIRE |
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