Reference intervals for human peripheral blood lymphocyte subpopulations from 'healthy' young and aged subjects
| Autor: | Otto Majdic, Georg Wick, Günther Böck, Christian Maczek, Thomas M. Stulnig |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Lymphocyte Immunology Age Factors General Medicine HLA-DR Antigens Biology Peripheral blood Lymphocyte Subsets Reference intervals Immunophenotyping medicine.anatomical_structure Lymphocyte subpopulations Antigen Antigens CD medicine Immunology and Allergy Humans Lymphocytes CD8 Lymphocyte subsets Aged |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1018-2438 |
| Popis: | Some lymphocyte subpopulations change during aging but age-related reference limits from a healthy reference population are still lacking. In this study, we compiled 90% reference intervals for commonly determined lymphocyte subpopulations in 'healthy' (Senieur-compatible) young (20-32 years) and elderly (65-74 years) subjects. The most striking age-related changes included increases in HLA-DR+ T lymphocytes, and the shift in the expression of CD45 isoforms from the CD45RA+CD45RO-to the CD45RA-CD45RO+ subset. Both age-related alterations occurred in the CD4+ as well as in the CD8+ subpopulations and most of them were present in the relative and absolute number of lymphocyte subsets. We compare our data with those from previous investigations on lymphocyte subpopulations from the elderly and comment on useful presentation of reference values. |
| Databáze: | OpenAIRE |
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