Distribution of systemic blood flow in lambs with an aortopulmonary shunt during strenuous exercise
| Autor: | J. W. C. Gratama, J. J. Meuzelaar, S. Gratama, W. G. Zijlstra, M Dalinghaus, Jaap R. G. Kuipers, J. H. Koers |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Cardiac output Aging Physiology Physical Exertion Hemodynamics Oxygen Consumption Physiology (medical) Internal medicine medicine.artery medicine Animals Cardiopulmonary Bypass Sheep business.industry Blood flow Organ Size Microspheres Diaphragm (structural system) Cerebral blood flow Animals Newborn Pulmonary artery Cardiology Blood Gas Analysis Splanchnic business Shunt (electrical) |
| Zdroj: | Journal of applied physiology (Bethesda, Md. : 1985). 73(4) |
| ISSN: | 8750-7587 |
| Popis: | We studied regional blood flows with radioactive-labeled microspheres in 12 7-wk-old lambs with an aortopulmonary left-to-right shunt [59 +/- 3% (SE) of left ventricular (LV) output] and in 11 control lambs, at rest and during exercise at 80% of predetermined peak O2 consumption. At rest, systemic blood flow was similar in the two groups. Blood flow to the heart and diaphragm was substantially higher in the shunt than in the control lambs. Blood flow to the other organs was not significantly different between the two groups. During exercise, systemic blood flow increased substantially but less in shunt (81%) than in control lambs (134%). Blood flow to the heart and diaphragm increased, that to the heart still being higher in shunt than in control lambs. Blood flow to the brain did not change, whereas that to the kidneys and splanchnic organs decreased to the same extent (25%) in shunt and control lambs. Intrahepatic and intrarenal blood flow redistribution in the shunt lambs persisted during exercise. In conclusion, myocardial blood flow is not increased at the expense of one particular organ, nor is it associated with an essential change in exercise-induced redistribution in shunt lambs. |
| Databáze: | OpenAIRE |
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