Identification of miR-124a as a novel diagnostic and prognostic biomarker in non-small cell lung cancer for chemotherapy

Autor: Ru‑Ting Xie, Qing‑Hua Zeng, Xiaofeng Wang, Xian‑Ling Cong, Da Fu, Le‑Le Cong, Wen-Ping Li, Yu‑Shui Ma, Qing Xia, Pei Luo, Qing Yang, Cheng‑You Jia, Xiao‑Ming Zhong, Hui‑Qiong Yang, Yu‑Sheng Li
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Oncology
Male
Cancer Research
Lung Neoplasms
medicine.medical_treatment
Kaplan-Meier Estimate
chemotherapy
Biochemistry
Metastasis
0302 clinical medicine
Carcinoma
Non-Small-Cell Lung
Neoplasm Metastasis
Articles
Middle Aged
Prognosis
Gene Expression Regulation
Neoplastic
030220 oncology & carcinogenesis
Molecular Medicine
Biomarker (medicine)
biomarker
Female
Databases
Nucleic Acid
Adult
medicine.medical_specialty
disease-free survival
overall survival
Biology
03 medical and health sciences
Internal medicine
Cell Line
Tumor
microRNA
Genetics
medicine
Biomarkers
Tumor
Humans
Lung cancer
Molecular Biology
non-small cell lung cancer
Aged
Neoplasm Staging
Proportional Hazards Models
Chemotherapy
Oncogene
Cancer
Computational Biology
medicine.disease
Molecular medicine
MicroRNAs
030104 developmental biology
microRNA-124
Neoplasm Grading
Zdroj: Molecular Medicine Reports
ISSN: 1791-3004
1791-2997
Popis: Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer. However, there are few studies reporting the level of miR‑124a expression in non‑small cell lung cancer (NSCLC). The present study investigated the association between miR‑124a and NSCLC by analyzing the differential expression of miR‑124a in NSCLC using the GEO database, as well as subsequently performing reverse transcription‑quantitative polymerase chain reaction analysis on 160 NSCLC biopsies, 32 of which were paired with adjacent normal tissues. The results indicated that mir‑124a expression levels were decreased in NSCLC tumor biopsies compared with adjacent normal tissues. The overall survival (OS) in patients with a high expression of miR‑124a was prolonged relative to patients with low expression of miR‑124a. The expression levels of miR‑124a were associated with clinical characteristics, including lymph‑node metastasis, tumor differentiation, tumor node metastasis (TNM) stage and diameter. Frequently, lymph‑node metastasis, TNM stage, diameter and lack of chemotherapy have been associated with a worse prognosis in patients. In addition, the present study identified that high expression of miR‑124awith chemotherapy may increase OS. In conclusion, the current study demonstrated that miR‑124a was downregulated in NSCLC, and miR‑124a was a potential prognostic tumor biomarker response to chemotherapy.
Databáze: OpenAIRE
Externí odkaz: