Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists
| Autor: | N. V. Glushchenko, G. I. Storozhakov, S. D. Mikhailova, T. M. Semushkina |
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| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Myocardial Ischemia Stimulation Ventricular tachycardia Dynorphins General Biochemistry Genetics and Molecular Biology Left coronary artery Internal medicine medicine.artery medicine Animals cardiovascular diseases Fibrillation CATS business.industry Motor Cortex Arrhythmias Cardiac General Medicine Enkephalin Ala(2)-MePhe(4)-Gly(5) medicine.disease Peptide Fragments Analgesics Opioid Idioventricular rhythm Receptors Opioid Ventricular fibrillation Cats cardiovascular system Cardiology medicine.symptom Opiate business Anti-Arrhythmia Agents Enkephalin Leucine |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 129:423-424 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A(1-13) on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex. The most pronounced effects were observed with DSLET and dinorphin A(1-13). These preparations completely prevented ventricular fibrillation. DAGO produced a less pronounced protective effect probably because of parallel increase in plasma catecholamine concentration. |
| Databáze: | OpenAIRE |
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