Wise retained in the endoplasmic reticulum inhibits Wnt signaling by reducing cell surface LRP6
| Autor: | Nobue Itasaki, Sonia Guidato |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
LRP6
Embryo Nonmammalian Xenopus Context (language use) Wnt1 Protein Endoplasmic Reticulum Cell Line Wnt3 Protein Wnt Xenopus laevis Animals Humans Molecular Biology Cellular localization LDL-Receptor Related Proteins Ectodin USAG-1 biology Endoplasmic reticulum Cell Membrane Wnt signaling pathway LRP5 Cell Biology biology.organism_classification Signaling Cell biology Wnt Proteins Low Density Lipoprotein Receptor-Related Protein-6 Wise Signal transduction Developmental Biology Signal Transduction |
| Zdroj: | Developmental biology. 310(2) |
| ISSN: | 0012-1606 |
| Popis: | The Wnt signaling pathway is tightly regulated by extracellular and intracellular modulators. Wise was isolated as a secreted protein capable of interacting with the Wnt co-receptor LRP6. Studies in Xenopus embryos revealed that Wise either enhances or inhibits the Wnt pathway depending on the cellular context. Here we show that the cellular localization of Wise has distinct effects on the Wnt pathway readout. While secreted Wise either synergizes or inhibits the Wnt signals depending on the partner ligand, ER-retained Wise consistently blocks the Wnt pathway. ER-retained Wise reduces LRP6 on the cell surface, making cells less susceptible to the Wnt signal. This study provides a cellular mechanism for the action of Wise and introduces the modulation of cellular susceptibility to Wnt signals as a novel mechanism of the regulation of the Wnt pathway. |
| Databáze: | OpenAIRE |
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