Eosinophil Knockout Humans: Uncovering the Role of Eosinophils through Eosinophil-Directed Biological Therapies
| Autor: | Elizabeth A. Jacobsen, Praveen Akuthota, Florence Roufosse, Albert J. Bredenoord, Marc E. Rothenberg, Ian D. Pavord, Enrico Heffler, Sameer K. Mathur, David A. Jackson |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biologic agents Immunology eosinophil knockout Biology eosinophil-deficient mice Article Proinflammatory cytokine Mice 03 medical and health sciences 0302 clinical medicine Immune system eosinophil-associated diseases medicine Animals Humans Immunology and Allergy eosinophil Interleukin 5 Gene knockout Mice Knockout IL-5 Biological therapies Sciences bio-médicales et agricoles Eosinophil respiratory system Biological Therapy Eosinophils 030104 developmental biology medicine.anatomical_structure Pharmaceutical Preparations 030228 respiratory system Knockout mouse Homeostasis |
| Zdroj: | Annu Rev Immunol Annual review of immunology, 39 |
| ISSN: | 0732-0582 |
| Popis: | The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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