Role of aluminum exposure on Alzheimer’s disease and related glycogen synthase kinase pathway

Autor:	PİNAR ERKEKOGLU, Gönül Şahin, Terken Baydar, Sonia Sanajou
Rok vydání:	2022
Předmět:	Pharmacology Chemical Health and Safety Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health General Medicine Toxicology
Zdroj:	Drug and Chemical Toxicology. 46:510-522
ISSN:	1525-6014 0148-0545
Popis:	Aluminum (Al) is an environmentally abundant metal that is not essential for life. There is considerable evidence that Al as a neurotoxic xenobiotic may play a role in the pathogenesis of neurodegenerative diseases like Alzheimer's disease (AD). Exposure to aluminum has been shown to cause neuronal damage that resembles the symptoms of AD. In this review, we will summarize recent data about Al as the possible risk of incidence of AD. Then glycogen synthase kinase-3 beta (GSK3β) contributes to the hyperphosphorylation of Tau protein, the main component of neurofibrillary tangles, one of the hallmarks of AD as one of the mechanisms behind Al neurotoxicity will be covered. Overall, there is still a need for epidemiological studies and more
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53a38902fae02f9720316a36980567c https://doi.org/10.1080/01480545.2022.2065291 Zobrazit plný text záznamu