A new diepoxy-ent-kauranoid, rugosinin, from Isodon rugosus
| Autor: | Atta-ur-Rahman, M. Iqbal Choudhary, Farzana Shaheen, Masood Parvez, Mudassir Asrar Zaidi, Yoshisuke Tsuda, Rasool Baksh Tareen, Zeba Parween, Ahmed Abbaskhan |
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| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Lasiokaurin biology Stereochemistry Chemical structure Organic Chemistry Isodon Absolute configuration Pharmaceutical Science Saccharomyces cerevisiae Pharmacognosy biology.organism_classification Crystallography X-Ray Terpenoid Triterpenes Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine Isodon rugosus chemistry Drug Discovery Molecular Medicine Diterpene |
| Zdroj: | Planta medica. 69(1) |
| ISSN: | 0032-0943 |
| Popis: | A new diterpenoid, rugosinin (1), isolated from Isodon rugosus, with absolute configuration was proved by single-crystal X-ray diffraction analysis, to be the member of a rare class of C-20/C-7 and C-20/C-14 diepoxy- ent-kauranoids. Effusanin A (2), effusanin B (3), effusanin E (4), lasiokaurin (5) and oridonin (6) were found as known constituents of the genus Isodon with C-20/C-7 epoxy function. These compounds have exhibited DNA-damaging activity in assay which employed DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. |
| Databáze: | OpenAIRE |
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