Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function
| Autor: | Jennifer, Sherr, William V, Tamborlane, Dongyuan, Xing, Eva, Tsalikian, Nelly, Mauras, Bruce, Buckingham, Neil H, White, Ana Maria, Arbelaez, Roy W, Beck, Craig, Kollman, Katrina, Ruedy, Vicky, Makky |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty β cell function Time Factors endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism Coefficient of variation medicine.medical_treatment 030209 endocrinology & metabolism Hypoglycemia law.invention 03 medical and health sciences 0302 clinical medicine Insulin Infusion Systems Randomized controlled trial law Internal medicine Diabetes mellitus Insulin-Secreting Cells Internal Medicine medicine Humans Hypoglycemic Agents Insulin Single-Blind Method 030212 general & internal medicine Child Pathophysiology/Complications Original Research Advanced and Specialized Nursing Glycated Hemoglobin Type 1 diabetes business.industry Incidence (epidemiology) Blood Glucose Self-Monitoring Incidence nutritional and metabolic diseases medicine.disease Endocrinology Diabetes Mellitus Type 1 Female business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 |
| Popis: | OBJECTIVE To determine exposure to hyper- and hypoglycemia using blinded continuous glucose monitoring (CGM) profiles in youth with type 1 diabetes (T1D) with residual β-cell function during the first year of insulin treatment. RESEARCH DESIGN AND METHODS Blinded, 3–7 day CGM profiles were obtained in 16 short-term T1D patients (age 8–18 years, T1D duration 6–52 weeks) who had peak C-peptide levels ranging from 0.46 to 1.96 nmol/L during a mixed-meal tolerance test. Results in this short-term group were compared with those in 34 patients with well-controlled, longer-term T1D (duration ≥5 years), matched for age and A1C with the short-term T1D group, and with those in 26 age-matched nondiabetic individuals. RESULTS Despite matching for A1C, and therefore similar mean sensor glucose levels in the two T1D groups, short-term T1D participants had a lower frequency of hypoglycemia (0.3 vs. 7.6%, P < 0.001), a trend toward less hyperglycemia (17 vs. 32%, P = 0.15), and a greater percentage in the target range (median 77 vs. 60%, P = 0.02). Indeed, the percentage of sensor glucose levels ≤70 mg/dL in the short-term T1D group (0.3%) did not differ from those in the nondiabetic group (1.7%, P = 0.73). The coefficient of variation of sensor glucose levels (an index of glucose variability) was lower in short-term vs. longer-term T1D participants (27 vs. 42%, respectively, P < 0.001). CONCLUSIONS In youth with short-term T1D who retain residual β-cell function, there is negligible exposure to hypoglycemia and lower glucose variability than in youth with well-controlled T1D of longer duration. |
| Databáze: | OpenAIRE |
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