Effects of Formulation and Dosing Strategy on Amprenavir Concentrations in the Seminal Plasma of Human Immunodeficiency Virus Type 1–Infected Men
| Autor: | Mary Beth Wire, Joseph J. Eron, Angela D. M. Kashuba, Arlene S. Pereira, Naumann I. Chaudry, Susan A. Fiscus, Odin J. Naderer |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Microbiology (medical) Anti-HIV Agents Chemistry Pharmaceutical HIV Infections Semen Pharmacology Virus Amprenavir Pharmacokinetics Blood plasma medicine Humans Prodrugs Furans Sulfonamides Ritonavir business.industry HIV Protease Inhibitors Prodrug Virology Organophosphates Regimen Infectious Diseases HIV-1 Carbamates business medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 35:760-762 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/342389 |
| Popis: | We compared seminal plasma pharmacokinetic data for the investigational amprenavir prodrug GW433908 with those for amprenavir and an amprenavir-ritonavir combination regimen. All 3 regimens resulted in detectable blood plasma and seminal plasma concentrations of amprenavir. The majority of these concentrations were greater than the plasma protein--corrected 50% inhibitory concentration for wild-type human immunodeficiency virus type 1. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|