MicroRNAs in glioblastoma pathogenesis and therapy: A comprehensive review
| Autor: | Howard Ozer, Sajani S. Lakka, Bhavesh K. Ahir, Herbert H. Engelhard |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Intracranial tumor Biology urologic and male genital diseases Bioinformatics Pathogenesis 03 medical and health sciences 0302 clinical medicine microRNA Biomarkers Tumor medicine Animals Humans Gene Brain Neoplasms urogenital system Astrocytoma Hematology medicine.disease Phenotype nervous system diseases MicroRNAs 030104 developmental biology Glioma grading Oncology 030220 oncology & carcinogenesis Glioblastoma |
| Zdroj: | Critical Reviews in Oncology/Hematology. 120:22-33 |
| ISSN: | 1040-8428 |
| Popis: | Glioblastoma (GBM), also known as grade IV astrocytoma, is the most aggressive primary intracranial tumor of the adult brain. MicroRNAs (miRNAs), a class of small non-coding RNA species, have critical functions across various biological processes. A great deal of progress has been made recently in dissecting miRNA pathways associated with the pathogenesis of GBM. miRNA expression signatures called gene signatures also characterize and contribute to the phenotypic diversity of GBM subclasses through their ability to regulate developmental growth and differentiation. miRNA molecules have been identified as diagnostic and prognostic biomarkers for patient stratification and may also serve as therapeutic targets and agents. This review summarizes: (i) the current understanding of the roles of miRNAs in the pathogenesis of GBM, (ii) the potential use of miRNAs in GBM diagnosis and glioma grading, (iii) further prospects of developing miRNAs as novel biomarkers and therapeutic targets for GBM, and (iv) important practical considerations when considering miRNA therapy for GBM patients. |
| Databáze: | OpenAIRE |
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