Pathological Studies of the Animals Replaced Totally with the Artificial Heart
| Autor: | Kazuhiko Atsumi, Hisashi Ohmichi, Kou Imachi, Isamu Mano, Yasuhisa Sakurai, Iwao Fujimasa, Isamu Kino, Tsuyoshi Nishisaka, Junichi Mori, Norishige Iwai |
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| Rok vydání: | 1976 |
| Předmět: |
Pathology
medicine.medical_specialty Infarction Pulmonary insufficiency Heart Artificial law.invention Postoperative Complications law Thromboembolism Artificial heart Ascites medicine Animals Cardiac Surgical Procedures Lung Pathological Endocardium business.industry Goats Myocardium Angiography Brain medicine.disease Microangiography Circulatory system cardiovascular system medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Japanese Heart Journal. 17:233-245 |
| ISSN: | 1348-673X 0021-4868 |
| DOI: | 10.1536/ihj.17.233 |
| Popis: | Pathological studies using routine pathological technics, microangiography and electron microscopy were performed on the 28 goats with an artificial heart (including 2 goats which survived for 30 and 37 days). In this paper, the brain, natural heart, and lungs of the goats were discussed. No special findings were seen in the brain except for rare infarcted areas. The natural heart almost always showed infarction-like lesions in the sub-endocardium and myocardium at the cut surface. The longer the animal survive, these findings became the more serious. The light microscopic findings on the lungs were classified into 6 groups. The most important findings of them are massive, diffuse exsudation with hemorrhage and its changes to chronic status. The main pathophysiological status, causing the pulmonary lesions, seemed to be peripheral circulatory insufficiency with increased permeability of peripheral vessels, especially of venulae. Thrombi were detected more frequently in the kidneys and lungs than in any other organs. The vascular walls where the thrombi were attached to, where often seen to be damaged, so that almost all thrombi were thought to be formed in the local vessels in situ, but not in the artificial heart. The main clinical causes to the pulmonary insufficiency were thought to be surgical operation including anesthesia, functional incompleteness of the artificial heart, etc. |
| Databáze: | OpenAIRE |
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