Strawberry-Shaped Skull in Fetal Trisomy 18
| Autor: | K.M. Nicolaides, D.R. Salvesen, C.M. Gosden, R.J.M. Snijders |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Embryology Aneuploidy Trisomy Prenatal diagnosis Ultrasonography Prenatal Pregnancy medicine Humans Abnormalities Multiple Radiology Nuclear Medicine and imaging Fetus Fetal Growth Retardation business.industry Skull Infant Newborn Obstetrics and Gynecology Occiput Syndrome General Medicine Anatomy Prognosis medicine.disease medicine.anatomical_structure Pediatrics Perinatology and Child Health Female Ultrasonography Chromosomes Human Pair 18 business |
| Zdroj: | Fetal Diagnosis and Therapy. 7:132-137 |
| ISSN: | 1421-9964 1015-3837 |
| DOI: | 10.1159/000263660 |
| Popis: | During an 8-year period, a strawberry-shaped skull (flattening of the occiput with pointing of the frontal bones), was observed in 54 (3%) of the 2,086 fetuses that underwent karyotyping in our unit because of fetal malformations and/or growth retardation. In all 54 cases with a strawberry-shaped skull, there were other fetal malformations; in 43 (80%) fetuses, there was trisomy 18 and in 1 triploidy. Therefore, the ultrasonographic finding of a strawberry-shaped skull should initiate a diligent search for the presence of other markers of trisomy 18 and is a strong indication for fetal karyotyping. However, in the total series of 2,086 fetuses with malformations and/or growth retardation, there were another 40 fetuses with trisomy 18 and 41 with triploidy who did not have a strawberry-shaped skull. |
| Databáze: | OpenAIRE |
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