Effect of ranitidine on gastroduodenal mucosal damage induced by nonsteroidal antiinflammatory drugs
| Autor: | John Bowers, Frederick J. Kogan, Joseph W. Griffin, David G. Kogut, Frank L. Lanza, Malcolm Robinson, Christopher W. Warner |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Naproxen Physiology Duodenum Piroxicam Placebo Ranitidine Gastroenterology Random Allocation Double-Blind Method Internal medicine medicine Humans Multicenter Studies as Topic Prospective Studies Stomach Ulcer Intestinal Mucosa Sulindac business.industry Stomach Anti-Inflammatory Agents Non-Steroidal Middle Aged Ibuprofen digestive system diseases medicine.anatomical_structure Gastric Mucosa Duodenal Ulcer Female business medicine.drug |
| Zdroj: | Digestive diseases and sciences. 34(3) |
| ISSN: | 0163-2116 |
| Popis: | The effect of ranitidine in preventing mucosal damage caused by nonsteroidal antiinflammatory drugs (NSAIDs) was evaluated for eight weeks in a prospective study of 144 patients requiring NSAIDs. Patients with normal endoscopic findings were randomly assigned to receive either ranitidine 150 mg twice daily or placebo for eight weeks, along with either ibuprofen, indomethacin, naproxen, sulindac, or piroxicam. Duodenal damage was significantly less in the ranitidine group compared with the placebo group by weeks 4 and 8 (P less than or equal to 0.01). Duodenal ulcers did not develop in any patients on ranitidine (0/57) compared with 4/49 patients (8%) on placebo (P = 0.02). No significant difference was found between treatment groups with respect to gastric damage; 6/60 (10%) in the ranitidine group compared with 6/50 (12%) in the placebo group developed gastric ulcers. These findings suggest that acid suppression is of greater importance for mucosal protection in the duodenum than in the stomach, where other defense mechanisms may be operative. While ranitidine is an effective prophylaxis for NSAID-induced damage in the duodenum, further studies are needed to define specific risk groups and to assess the potential usefulness of more complete acid suppression in preventing gastric mucosal damage. |
| Databáze: | OpenAIRE |
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